1243322-14-6Relevant articles and documents
Chemoenzymatic asymmetric total synthesis of (S)-Rivastigmine using ω-transaminases
Fuchs, Michael,Koszelewski, Dominik,Tauber, Katharina,Kroutil, Wolfgang,Faber, Kurt
, p. 5500 - 5502 (2010)
A straightforward, high-yielding, chemoenzymatic total synthesis of enantiopure (S)-Rivastigmine was developed using various ω-transaminases for the asymmetric amination of appropriate acetophenone precursors. Optimisation of the biotransformation allowed scale-up and the total synthesis of (S)-Rivastigmine. The Royal Society of Chemistry 2010.