139306-10-8 Usage
Description
3-[(1S)-1-(Dimethylaminoethyl)]phenol, also known as NAP 226-90, is a metabolite of Rivastigmine that is formed by hydrolysis. It is an off-white to pale yellow crystalline compound with the molecular formula C10H15NO and a molecular weight of 165.23 g/mol. Rivastigmine is a brain-selective acetylcholinesterase inhibitor, which means that it helps to increase the levels of acetylcholine in the brain, thereby improving cognitive function and memory in patients with Alzheimer's disease and other dementia-related conditions.
Uses
Used in Pharmaceutical Industry:
3-[(1S)-1-(Dimethylaminoethyl)]phenol is used as an active pharmaceutical ingredient (API) for the development of drugs targeting cognitive impairment and dementia. Its application is based on its role as a metabolite of Rivastigmine, which is a brain-selective acetylcholinesterase inhibitor. This makes it a promising candidate for the treatment of Alzheimer's disease and other related conditions, as it can help improve cognitive function and memory.
Used in Research and Development:
3-[(1S)-1-(Dimethylaminoethyl)]phenol is also used in research and development for the study of its chemical properties, synthesis methods, and potential applications in the pharmaceutical industry. Researchers can use this compound to investigate its interactions with other molecules, its stability, and its potential as a precursor for the synthesis of other related compounds with therapeutic potential.
Used in Quality Control and Impurity Profiling:
In the pharmaceutical industry, 3-[(1S)-1-(Dimethylaminoethyl)]phenol is used as a reference standard for quality control and impurity profiling of Rivastigmine. This is important to ensure the safety, efficacy, and purity of the drug, as well as to comply with regulatory requirements for drug approval and manufacturing processes.
Used in Drug Delivery Systems:
Similar to Gallotannin, 3-[(1S)-1-(Dimethylaminoethyl)]phenol can also be used in the development of novel drug delivery systems to enhance its applications and efficacy against cognitive impairment and dementia. Various organic and metallic nanoparticles can be employed as carriers for this compound, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 139306-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,3,0 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 139306-10:
(8*1)+(7*3)+(6*9)+(5*3)+(4*0)+(3*6)+(2*1)+(1*0)=118
118 % 10 = 8
So 139306-10-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H15NO/c1-8(11(2)3)9-5-4-6-10(12)7-9/h4-8,12H,1-3H3/t8-/m0/s1
139306-10-8Relevant articles and documents
Purification method of carafine intermediate
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, (2021/10/02)
To 3 - hydroxyacetophenone as a raw material, the intermediate 3 - [1 - (dimethylamino) ethyl] phenol is formed by reaction with dimethylamine, and the intermediate is subjected to resolution and purification by a specific resolution system to obtain S - 3 - [1 - (dimethylamino) ethyl] phenol. Compared with the preparation method of the intermediate prepared by the method, the preparation method has the advantages of low cost, high yield, good effect, less environmental pollution, reduced residue of inorganic salt, and favorability for large-scale industrial production.
SYNTHESIS OF NOVEL INTERMEDIATE(S) FOR PREPARING RIVASTIGMINE
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Paragraph 0074, (2020/04/10)
The present invention relates to novel intermediate(s), which are useful for the preparation of Rivastigmine compound of formula (I) and its pharmaceutically acceptable salts. The present invention further relates to the processes for the preparation of such novel intermediate(s) and preparation of Rivastigmine using such novel intermediate(s).
Iridium-catalyzed diastereoselective amination of alcohols with chiral: Tert-butanesulfinamide by the use of a borrowing hydrogen methodology
Xi, Xiaomei,Li, Yongjie,Wang, Guannan,Xu, Guangda,Shang, Lina,Zhang, Yao,Xia, Lixin
supporting information, p. 7651 - 7654 (2019/08/30)
An iridium-catalyzed diastereoselective amination of alcohols with chiral tert-butanesulfinamide was developed under basic conditions, affording the optically active secondary sulfinamides in high yields and diastereoselectivities. The removal of the sulfinyl group from sulfonamides allowed a facile access to a wide range of α-chiral primary amines. This synthetic strategy was further applied in the synthesis of the marketed pharmaceuticals (S)-rivastigmine and NPS R-568.
