105601-04-5

Basic information

• Product Name: 3-(1-(Dimethylamino)ethyl]phenol
• Synonyms: (R)-3-(1-(DIMETHYLAMINO)ETHYL)PHENOL;PHENOL, 3-[1-(DIMETHYLAMINO)ETHYL]-;Rivastigmine Intermediate 2;3-[1-dimethylamino]ethyl]pheno;(R)-3-1(-DIMETHYLAMINO)ETHYLPHENOL,98%;3-(1-(dimethylamino)ethyl)phenol HBr (racemate);N,N-Dimethyl-N-[1-(3’-hydroxyphenyl)ethyl]amine;ZNS 114-666
• CAS NO: 105601-04-5
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.23
• EINECS: 1308068-626-2
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Intermediate of Rivastigmine
• Mol File: 105601-04-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 87-89°C
• Boiling Point: 241℃
• Flash Point: 97℃
• Appearance: pale brown solid
• Density: 1.021
• Vapor Pressure: 0.0233mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: -20?C Freezer
• Solubility: soluble in Methanol
• PKA: 9.86±0.10(Predicted)
• CAS DataBase Reference: 3-(1-(Dimethylamino)ethyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-(Dimethylamino)ethyl]phenol(105601-04-5)
• EPA Substance Registry System: 3-(1-(Dimethylamino)ethyl]phenol(105601-04-5)

Safety Data

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45
• Hazardous Substances Data: 105601-04-5(Hazardous Substances Data)

Usage

Chemical Properties

Pale Brown Solid

Uses

An active (major) metabolite of Rivastigmine

InChI:InChI=1/C10H15NO/c1-8(11(2)3)9-5-4-6-10(12)7-9/h4-8,12H,1-3H3/t8-/m1/s1

Upstream product

• 591-31-1 3-methoxy-benzaldehyde 
• 121-71-1 3-Hydroxyacetophenone 
• 124-40-3 dimethyl amine 
• 50-00-0 formaldehyd 
• 75-24-1 trimethylaluminum 
• 2415-09-0 3-(1-hydroxyethyl)phenol 
• 506-59-2 N,N-dimethylammonium chloride 
• 2454-36-6 m-Acetoxyphenyl-methyl-carbinol 
• 5441-61-2 (+/-)-3-(1-dimethylamino-ethyl)-phenol; hydrochloride 
• 63720-38-7 3-hydroxy-α-methylbenzylamine 
• 89691-63-4 1-(3-methoxy)-phenylethanol 
• 58114-05-9 1-chloro-1-(3'-methoxyphenyl)ethane 
• 923035-06-7 3-((1-methylamino)ethyl)phenol 
• 129052-92-2 N,N-dimethyl-α-(m-methoxyphenyl)ethylamine 

Downstream Products

• 105601-04-5 (+)-3-(1-dimethylamino-ethyl)-phenol 
• 105601-04-5 (-)-3-(1-dimethylamino-ethyl)-phenol 
• 4464-16-8 methyl-carbamic acid-[3-(1-dimethylamino-ethyl)-phenyl ester] 
• 4464-16-8 (-)-methyl-carbamic acid-[3-(1-dimethylamino-ethyl)-phenyl ester] 
• 4464-16-8 (+)-methyl-carbamic acid-[3-(1-dimethylamino-ethyl)-phenyl ester] 
• 798561-06-5 C₁₀H₁₅NO*C₁₀H₁₆O₄S 
• 105601-14-7 N-ethyl-3-[(1-dimethylamino)ethyl]-N-methylphenylcarbamate hydrochloride 
• 1350432-40-4 tert-butyl 3-(3-(1-(dimethylamino)ethyl)phenoxy)propylcarbamate 
• 105601-20-5 rac-rivastigmine 
• 123441-03-2 rivastigmine tartrate 
• 123441-03-2 rivastigmin 
• 903588-24-9 N-(3-(3-(1-(dimethylamino)ethyl)phenoxy)propyl)-5-(1,2-dithiolan-3-yl)pentanamide 
• 903588-33-0 3-(3-(1-(dimethylamino)ethyl)phenoxy)propan-1-amine 
• 139306-10-8 (S)-3-(1-dimethylaminoethyl)phenol 

Relevant articles and documents

Purification method of carafine intermediate

To 3 - hydroxyacetophenone as a raw material, the intermediate 3 - [1 - (dimethylamino) ethyl] phenol is formed by reaction with dimethylamine, and the intermediate is subjected to resolution and purification by a specific resolution system to obtain S - 3 - [1 - (dimethylamino) ethyl] phenol. Compared with the preparation method of the intermediate prepared by the method, the preparation method has the advantages of low cost, high yield, good effect, less environmental pollution, reduced residue of inorganic salt, and favorability for large-scale industrial production.

A 3 - [1 - (dimethylamino) ethyl] phenol preparation method

The invention provides a method for preparing 3-[1-(dimethylamino)ethyl]phenol II. According to the method, by the following reaction formula shown in the description, 3-[1-(methylamino)ethyl)phenol III is prepared from meta-hydroxyl acetophenone IV, which serves as a raw material, through leuckart reaction and is subjected to eschweiler-clarke reaction so as to obtain 3-[1-(dimethylamino)ethyl]phenol II. The method provided by the invention has the advantages that the synthesis route is short, the raw material is cheap and easily available, hazardous and noxious substances are not required to be used, the operation is easy, the production cost is low, and the problems such as complicated reaction operation, high cost, low yield and the like in the prior art are solved. The method is applicable to industrial production and has a relatively high application value.

1 -(DIMETHYLAMINO)ETHYL-SUBSTITUTED 6H-BENZO[C]CHROMEN-6-ONES AGAINST SENILE DEMENTIA

This invention relates to novel (±)1-(Dimethylamino)ethyl substituted 6H-benzo[c]chromen-6-one compounds which are useful as pharmaceutical compositions.