124397-37-1Relevant articles and documents
Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors
Dias, Marcio Vinícius Bertacine,Ferreira, Glaucio Monteiro,Kronenberger, Thales,Parise-Filho, Roberto,Pavan, Fernando Rogério,Poso, Antti,Ribeiro, Jo?o Augusto,Tavares, Maurício Temotheo,Trossini, Gustavo Henrique Goulart,da Silva Santos, Soraya,de Souza, Alfredo Danilo Ferreira
, (2020/07/03)
The enzyme dihydrofolate reductase from M. tuberculosis (MtDHFR) has a high unexploited potential to be a target for new drugs against tuberculosis (TB), due to its importance for pathogen survival. Preliminary studies have obtained fragment-like molecule
Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents
Xie, Rui,Yao, Yue,Tang, Pingwah,Chen, Guangyao,Liu, Xia,Yun, Fan,Cheng, Chunhui,Wu, Xinying,Yuan, Qipeng
, p. 1 - 12 (2017/04/11)
Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, we designed and synthesized two series of hydroxamates and 2-aminobenzamides
Modulators of methyl modifying enzymes, compositions and uses thereof
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Page/Page column 116; 117, (2015/12/26)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
