1244949-62-9 Usage
Description
2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone is an organic compound that serves as a crucial intermediate in the synthesis of pharmaceuticals. It is characterized by its unique molecular structure, which includes a chloro group, a cyclopentylamino group, and a pyrimidinyl ethanone moiety. 2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone plays a significant role in the development of targeted cancer therapies.
Uses
Used in Pharmaceutical Industry:
2-chloro-4-(cyclopentylamino)-5-pyrimidinyl ethanone is used as a key reagent for the preparation of Palbociclib, a drug specifically designed for the treatment of ER-positive and HER-negative breast cancer. Its unique chemical properties allow for the selective inhibition of cyclin-dependent kinases (CDKs), which play a critical role in the regulation of cell cycle progression. By inhibiting these enzymes, Palbociclib can effectively arrest the cell cycle and prevent the growth and proliferation of cancer cells, making it a valuable tool in the fight against breast cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1244949-62-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,9,4 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1244949-62:
(9*1)+(8*2)+(7*4)+(6*4)+(5*9)+(4*4)+(3*9)+(2*6)+(1*2)=179
179 % 10 = 9
So 1244949-62-9 is a valid CAS Registry Number.
1244949-62-9Relevant articles and documents
Novel synthetic method of Palbociclib
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, (2017/08/22)
The invention provides a novel synthetic method of Palbociclib, comprising the following steps: 1) under the action of alkali and a solvent, an intermediate V and an intermediate B1 undergo a condensation reaction to obtain a compound VI; 2) the compound VI undergoes exchange with a Grignard reagent, and then the exchange reaction product reacts with an acylation reagent to obtain a compound VII; when X is acetyl, the compound VI is the compound VII; 3) the compound VII undergoes deprotection reaction under the action of hydroxyethanesulphonic acid and finally salification is conducted so as to obtain the finished product Palbociclib X. the synthetic method has a simple process route, is low-cost, and is suitable for industrial production. The synthetic route is as shown in the specification.
