1651214-74-2

Basic information

• Product Name: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
• Synonyms: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate;4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;8-Cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-6-vinyl-8H-pyrido[2,3-d]pyrimidin-7-one
• CAS NO: 1651214-74-2
• Molecular Formula: C29H37N7O4
• Molecular Weight: 547.64858
• Mol File: 1651214-74-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 746.4±70.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• PKA: 5.24±0.10(Predicted)
• CAS DataBase Reference: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate(1651214-74-2)
• EPA Substance Registry System: tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate(1651214-74-2)

Safety Data

• Hazardous Substances Data: 1651214-74-2(Hazardous Substances Data)

Usage

Description

tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate is a complex organic compound with a unique molecular structure. It is characterized by a tert-butyl group, a piperazine-1-carboxylate moiety, and a pyridin-3-yl group connected to a pyrido[2,3-d]pyrimidin-2-yl core with various substituents. tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate has potential applications in various fields due to its specific chemical properties and interactions.

Uses

Used in Pharmaceutical Industry:
tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate is used as a precursor in the synthesis of pharmaceutical compounds. Its unique structure allows it to be a key intermediate in the production of drugs targeting specific biological pathways.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, this compound serves as a valuable research tool. It can be used to study the interactions between various molecular targets and potential drug candidates, aiding in the development of new therapeutic agents.
Used in Drug Design and Development:
Due to its specific structural features, tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate can be employed in drug design and development processes. It may contribute to the creation of novel drugs with improved efficacy and selectivity.

Upstream product

• 571189-03-2 8-cyclopentyl-2-[[5-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]amino]-7,8-dihydro-5-methyl-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester 
• 917-54-4 methyllithium 
• 65221-10-5 2-acetyl-but-2-enoic acid methyl ester 
• 733038-80-7 tert-butyl 4-(6-{[5-bromo-4-(cyclopentylamino)pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate 
• 571189-22-5 4-[6-(8-cyclopentyl-6-iodo-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)pyridin-3-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 571188-82-4 tert?butyl 4?(6?((6?bromo?8?cyclopentyl?5?methyl?7?oxo?7,8?dihydropyrido[2,3?d]pyrimidin?2?yl)amino)pyridin?3?yl)piperazine?1?carboxylate 
• 571188-59-5 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 
• 1244949-62-9 C₁₁H₁₄ClN₃O 
• 866084-31-3 tert?butyl 4?(6?((6?(1?butoxyvinyl)?8?cyclopentyl?5?methyl?7?oxo?7,8?dihydropyrido[2,3?d]pyrimidin?2?yl)amino)pyridin?3?yl)piperazine?1?carboxylate 
• 1016636-76-2 2-chloro-5-methyl-6-bromo-8-cyclopentylpyridine[2,3-d]pyrimidin-8-hydro-7-one 
• 1013916-37-4 2-chloro-5-methyl-8-cyclopentylpyridin[2,3-d]pyrimidin-8-hydro-7-one 

Relevant articles and documents

Preparation method of palbociclib

The invention provides a preparation method of palbociclib. Specifically, ethyl acetoacetate and acetaldehyde are subjected to condensation hydrolysis to prepare 2-acetyl-2-butenoic acid instead of crotonic acid, and tedious steps such as acetyl group loading are not needed, so a synthesis route is simplified. The preparation method is simple and safe, product purity is high, and product yield is improved.

Simple preparation method of palmemonil (by machine translation)

The invention provides a simple preparation method, and belongs to the field of preparation. 2 -acetyl -3 -methyl -2 -methylpyridine 3 -1 - (1H, 5H) - diketone (III), and a hydroformylation reagent are then condensed to prepare -4 -acetyl -2-cyclopentyl 6 -methyl 3 -dialkylaminopyridylpyridine -1 -5 - 6 -2 -4 - (1H, 5H) - diketone (IV) . Further to N - [5 - (4 -tert-butoxycarbonyl piperazine -1 -yl) pyridin -2 -yl] guanidine (V) is cyclized to obtain Boc-protected pbast (VI) . deBoc protecting group gave palbotanil (I). The method is short, simple and convenient to operate, easy to implement, low in cost, less in three wastes, and high in product purity and yield. (by machine translation)

Novel synthetic method of Palbociclib

The invention provides a novel synthetic method of Palbociclib, comprising the following steps: 1) under the action of alkali and a solvent, an intermediate V and an intermediate B1 undergo a condensation reaction to obtain a compound VI; 2) the compound VI undergoes exchange with a Grignard reagent, and then the exchange reaction product reacts with an acylation reagent to obtain a compound VII; when X is acetyl, the compound VI is the compound VII; 3) the compound VII undergoes deprotection reaction under the action of hydroxyethanesulphonic acid and finally salification is conducted so as to obtain the finished product Palbociclib X. the synthetic method has a simple process route, is low-cost, and is suitable for industrial production. The synthetic route is as shown in the specification.