1246203-83-7

Basic information

• Product Name: benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate
• Synonyms: benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate
• CAS NO: 1246203-83-7
• Molecular Weight: 369.485
• Mol File: 1246203-83-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate(1246203-83-7)
• EPA Substance Registry System: benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate(1246203-83-7)

Safety Data

• Hazardous Substances Data: 1246203-83-7(Hazardous Substances Data)

Upstream product

• 287953-54-2 4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester 
• 108-00-9 N,N-dimethylethylenediamine 

Relevant articles and documents

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474

Replacing one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 with a variety of sulfonamide-linked solubilizing substituents produced a new class of active and potent PI3Kα inhibitors, with several derivatives demonstrating high PI3Kα enzyme potency and good cellular potency in two human derived cell lines. The overall results suggest a preference for linear and somewhat flexible solubilizing functions. From this series, compound 16, also known as SN32976, was selected for advanced preclinical evaluation.