287953-54-2

Basic information

• Product Name: N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE
• Synonyms: Benzyl 4-(chlorosulfonyl)tetrahydro-1(2H)-pyridinecarboxylate;1-PIPERIDINECARBOXYLIC ACID, 4-(CHLOROSULFONYL)-,PHENYLMETHYL ESTER;4-CHLOROSULFONYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;Piperidine-4-sulphonyl chloride, N-CBZ protected;benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate;N-[(Benzyloxy)carbonyl]piperidine-4-sulphonyl chloride, Benzyl 4-(chlorosulphonyl)piperidine-1-carboxylate;N-CBZ-4-PIPERIDINE SULFONYL CHLORIDE;PIPERIDINE-4-SULFONYL CHLORIDE, N-CBZ PROTECTED
• CAS NO: 287953-54-2
• Molecular Formula: C₁₃H₁₆ClNO₄S
• Molecular Weight: 317.79
• Mol File: 287953-54-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 159.9℃
• Boiling Point: 454.864 °C at 760 mmHg
• Flash Point: 228.894 °C
• Appearance: /
• Density: 1.396 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.77±0.40(Predicted)
• CAS DataBase Reference: N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE(287953-54-2)
• EPA Substance Registry System: N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE(287953-54-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 287953-54-2(Hazardous Substances Data)

Usage

General Description

N-Benzyloxycarbonyl-4-piperidinesulfonyl chloride is a chemical compound used primarily in the field of organic chemistry. As a sulfonamide type organic compound, it forms part of various chemical reactions, particularly in the synthesis of other complex organic compounds. N-BENZYLOXYCARBONYL-4-PIPERIDINESULFONYL CHLORIDE is also characterized by the presence of the benzyloxycarbonyl (also known as the carbobenzoxy or Cbz) protective group, which is often used in peptide synthesis. Its properties and usage in chemical reactions make it an important substance in pharmaceutical and biochemical research. However, like many other chemical substances, it must be carefully handled and stored due to its potential reactivity and toxicity.

InChI:InChI=1/C13H16ClNO4S/c14-20(17,18)12-6-8-15(9-7-12)13(16)19-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2

Upstream product

• 166953-64-6 benzyl 4-bromo-1-piperidinecarboxylate 
• 90633-18-4 4-bromo-1H-piperidine 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 199103-19-0 benzyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 146827-60-3 4-(acetylthio)-1-(benzyloxycarbonyl)piperidine 

Downstream Products

• 878388-35-3 benzyl 4-sulfamoylpiperidine-1-carboxylate 
• 622387-28-4 benzyl 4-{[4-(5-bromopyridin-2-yl)piperidin-1-yl]sulfonyl}piperidine-1-carboxylate 
• 622386-85-0 C₂₈H₃₈N₂O₅S 
• 622386-76-9 C₂₉H₄₀N₂O₄S 
• 633312-80-8 C₂₈H₃₆N₄O₆S 
• 956075-49-3 N,N-dimethyl-4-piperidinesulfonamide 
• 1426154-26-8 benzyl 4-({[2-chloro-6-(morpholin-4-yl)pyrimidin-4-yl]methyl}sulfonyl)piperidine-1-carboxylate 
• 1616974-33-4 sodium 1-[(benzyloxy)carbonyl]piperidine-4-sulfinate 
• 1428973-10-7 benzyl 4-((3-(2-chloro-2-phenylacetyl)-1H-indol-1-yl)sulfonyl)piperidine-1-carboxylate 
• 1312592-79-2 phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate 
• 1344125-12-7 C₂₆H₃₃N₅O₄S₂ 
• 1196150-83-0 4-(1-Hydroxy-1,3-dihydro-benzo[c][1,2]oxaborol-6-ylsulfamoyl)-piperidine-1-carboxylic acid benzyl ester 
• 1246203-83-7 benzyl 4-[[[2-(dimethylamino)ethyl]amino]sulfonyl]-1-piperidinecarboxylate 

Relevant articles and documents

NOVEL SULFONAMIDE CARBOXAMIDE COMPOUNDS

The present invention relates to compounds of formula (I) wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the α-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Rho KINASE INHIBITORS

-