622386-76-9

Basic information

• Product Name: C₂₉H₄₀N₂O₄S
• Synonyms: C₂₉H₄₀N₂O₄S
• CAS NO: 622386-76-9
• Molecular Weight: 512.714
• Mol File: 622386-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₄₀N₂O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₄₀N₂O₄S(622386-76-9)
• EPA Substance Registry System: C₂₉H₄₀N₂O₄S(622386-76-9)

Safety Data

• Hazardous Substances Data: 622386-76-9(Hazardous Substances Data)

Upstream product

• 287953-54-2 4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester 
• 622386-75-8 C₁₆H₂₅N 

Downstream Products

• 622386-77-0 C₃₁H₄₂N₂O₆S 

Relevant articles and documents

Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.