1246464-10-7

Basic information

• Product Name: 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine
• Synonyms: 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine
• CAS NO: 1246464-10-7
• Molecular Weight: 304.274
• Mol File: 1246464-10-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(1246464-10-7)
• EPA Substance Registry System: 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(1246464-10-7)

Safety Data

• Hazardous Substances Data: 1246464-10-7(Hazardous Substances Data)

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 1233246-24-6 3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-amine 
• 3038-47-9 2-(trifluoromethyl)phenylacetonitrile 
• 1191445-85-8 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine 

Downstream Products

• 1246464-14-1 C₂₃H₁₃F₃N₄O₂ 

Relevant articles and documents

A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives

Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for their in vitro antibacterial activity against gram-positive bacteria such as (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) and also evaluated for their antifungal activity against Aspergillus Niger and Helmenthosphorium oryzae fungal strains. Some of the products demonstrate good antibacterial activity and moderate antifungal activity. In predominantly, 8b, 8d, 8g, and 8h compounds showed good to excellent antibacterial and antifungal activities. The antimicrobial activity of the compound 8 was further investigated with the help of in LibDock score docking study to predict the active sites. Graphical abstract: [Figure not available: see fulltext.].

Environmentally benign synthesis, antibacterial and anti-inflammatory activities of 3-aryl-1-{3-[2-(trifluoromethyl) phenyl][1,8]naphthyridin-2-yl}-1H-4-pyrazolecarbaldehydes

A simple and efficient protocol for the transformation of 1-aryl-1-ethanone 1-{3-[2-(trifluoromethyl)phenyl][1,8]naphthyridin-2-yl}hydrazones 3 to 3-aryl-1-{3-[2-(trifluoromethyl) phenyl][1,8]-naphthyridin-2-yl}-1H-4-pyrazolecarbaldehydes 4 is reported under microwave irradiation utilizing POCl3-DMF over silica gel with high yields. The structures of the compounds 3 and 4 have been confirmed on the basis of their elemental analyses and spectral (IR, 1H NMR and MS) data. The compounds 4 have been evaluated for their antibacterial and anti-inflammatory activities.