124791-80-6

Basic information

• Product Name: C₁₂H₁₅NO₃
• Synonyms: C₁₂H₁₅NO₃
• CAS NO: 124791-80-6
• Molecular Weight: 221.256
• Mol File: 124791-80-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₅NO₃(124791-80-6)
• EPA Substance Registry System: C₁₂H₁₅NO₃(124791-80-6)

Safety Data

• Hazardous Substances Data: 124791-80-6(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 623-47-2 propynoic acid ethyl ester 
• 141-97-9 ethyl acetoacetate 
• 34780-29-5 3-oxo-propionic acid ethyl ester 

Downstream Products

• 1407997-30-1 4′-methoxyphenylamino-bis[(2-methyl)-4,5-diphenyl-1-4′-methoxyphenyl-1H-pyrrole-3-carboxylic acid ethyl ester] 
• 1418218-57-1 4-(carboxymethyl)-1-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 
• 1236203-51-2 diethyl 4-(2-ethoxy-2-oxoethyl)-1-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes

A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1?mol?%.

CeCl3·7H2O catalyzed C-C and C-N bond-forming cascade cyclization with subsequent side-chain functionalization and rearrangement: A domino approach to pentasubstituted pyrrole analogues

CeCl3·7H2O is found as an efficient catalyst for new intermolecular domino reactions of three-, four- and seven-component assemblies of common precursors under benign reaction conditions. Generation of enaminioesters from β-keto esters and primary amines, activation of their allylic sp3 C-H, vinylic sp2 C-H and N-H bonds, multi C-C and C-N bond-forming cascade cyclization with 1,2-diketones and subsequent side-chain alkylation have been developed to construct functionalized pentasubstituted pyrroles and their chiral analogues. The scope of the domino reaction is successfully explored toward synthesis of highly aryl-substituted pyrroles, pentasubstituted pyrroles bearing C2-olefinic side-chain and spiro-2-pyrrolinones and their chiral analogues via unusual side-chain amination, elimination and ring contraction. The new domino reaction is operationally simple, robust, substrate specific, selective and high yielding.

ENZYMATIC SYNTHESIS OF PROPARGYLAMIDES

A lipase (Candida cylindracea) catalyzed the reaction between ethyl propiolate and aromatic amines to afford propargylamides.