34780-29-5Relevant articles and documents
An improved and large scale synthesis of the natural coumarin scopoletin
Hauer,Ritter,Grotemeier
, p. 737 - 738 (1995)
Isovanillin was oxidized with magnesium monoperoxyphthalate to 4-methoxyresorcinol (2) and the latter was reacted with 3-oxo-propionic acid ethylester prepared in situ to give scopoletin (1). These reactions can be achieved in kg scale in high yields.
Preparation method of 3-N,N-dimethylamino ethyl acrylate
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Paragraph 0038, (2016/10/08)
The present invention provides a preparation method of 3-N,N-dimethylamino ethyl acrylate. According to the method, a 3-N,N-dimethylamino ethyl acrylate crude product and a polymerization inhibitor are mixed and subjected to reduced pressure distillation, and 3-N,N-dimethylamino ethyl acrylate is obtained; the polymerization inhibitor in use is composed two or more of 2,6-binitro p-cresol, o-sec-4,6-dinitrophenol, 2, 4-dimethyl-6-tertiary butyl phenol, 2,6-binitro-p-cresol, 2,2,6,6-tetramethylpiperidine nitric oxide, 2,2,6,6-tetramethyl-4-piperidone, N-methyl-2-pyrrolidone, dimethyl-thioltoluenediamine and an organic sulfonic acid compound. The specific polymerization inhibitor and the 3-N,N-dimethylamino ethyl acrylate crude product are selected and mixed to be subjected to reduced pressure distillation, the purity of 3-N,N-dimethylamino ethyl acrylate obtained through distillation is high, and the yield is also high.
2-(1-HETEROARYLPIPERAZIN-4-YL)METHYL-1,4-BENZODIOXANE DERIVATIVES AS ALPHA2C ANTAGONISTS
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Page/Page column 24, (2016/12/22)
Compounds of formula I (formula I), wherein A is an optionally substituted five-membered unsaturated heterocyclic ring containing 1, 2 or 3 N, O or S ring heteroatom(s) exhibit alpha2C antagonistic activity and are thus useful for the treatment of diseases or conditions of the peripheric or central nervous system.