124980-95-6

Basic information

• Product Name: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-
• CAS NO: 124980-95-6
• Molecular Formula: C9H9FO
• Molecular Weight: 152.168
• Mol File: 124980-95-6.mol
• Article Data: 84

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(124980-95-6)
• EPA Substance Registry System: 2-Propen-1-ol, 3-(4-fluorophenyl)-, (2E)-(124980-95-6)

Safety Data

• Hazardous Substances Data: 124980-95-6(Hazardous Substances Data)

Upstream product

• 24393-50-8 ethyl 4-fluorocinnamate 
• 5724-03-8 1-(4-fluorophenyl)allyl alcohol 
• 459-57-4 4-fluorobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 1737-16-2 1-allyl-4-fluorobenzene 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 459-32-5 4-fluorocinnamic acid 
• 51791-26-5 3-(4-fluoro-phenyl)-propenal 
• 100891-10-9 methyl p-fluorocinnamate 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 31736-68-2 2-(4'-fluorophenyl)oxetane 

Downstream Products

• 1137838-06-2 tert-butyl (E)-3-(4'-fluorophenyl)prop-2-en-1-yl carbonate 
• 1147334-94-8 C₉H₅FN₂O₃ 
• 1147334-68-6 4-(4-fluorophenyl)-3-(hydroxymethyl)-1,2,5-oxadiazole 2-oxide 
• 1093173-69-3 C₂₉H₃₅F₄NO₅ 
• 1304683-82-6 (2S,3S)-tert-butyl3-(4-fluorophenyl)-2-cyano-2-ethylpent-4-enoate 
• 1351469-23-2 C₁₀H₁₃FO₂ 
• 1346682-15-2 (E)-1-(3-(but-3-ynyloxy)prop-1-enyl)-4-fluorobenzene 
• 1346682-21-0 2-((but-3-ynyloxy)methyl)-3-(4-fluorophenyl)oxirane 
• 1346682-24-3 1-(4-fluorophenyl)-3-(prop-2-ynyloxy)propan-2-one 
• 1346682-28-7 1-(but-3-ynyloxy)-3-(4-fluorophenyl)propan-2-one 
• 1346682-33-4 1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)prop-2-ynyloxy)propan-2-one 
• 1346682-36-7 1-(3-(4-chlorophenyl)prop-2-ynyloxy)-3-(4-fluorophenyl)propan-2-one 
• 1346682-40-3 1-(4-(3,5-dimethylphenyl)but-3-ynyloxy)-3-(4-fluorophenyl)propan-2-one 
• 1346682-72-1 5-(3,5-dimethylphenyl)-7-fluoro-3,4-dihydro-1H-benzo[g]isochromene 

Relevant articles and documents

Synthesis and in vitro pharmacological behavior of platinum(II) complexes containing 1,2-diamino-1-(4-fluorophenyl)-2-alkanol ligands

In continuation of our effort to optimize the pharmacological profile of [1,2-diamino-1,2-bis(4-fluorophenyl)ethane]dichloridoplatinum(II) complexes, we synthesized [1,2-diamino-1-(4-fluorophenyl)alkanol]dichloridoplatinum(II) analogs. The aim of this study was to evaluate the influence of hydroxyl groups at the C2 moiety on aqueous solubility, lipophilicity, cellular platinum accumulation, and cytotoxicity against MDA-MB-231, U-937, RAJI, and SC-1 cells as well as against cisplatin-sensitive and cisplatin-resistant A2780 and A2780cisR ovarian carcinoma cells. As expected, the OH groups improved the water solubility and decreased the lipophilicity of the neutral ligands, resulting in complexes with favorable pharmacokinetic properties. The cellular uptake of the compounds in MDA-MB-231 and U-937 cells proved to depend on the configuration and showed only a slight correlation with lipophilicity. The most active complexes were R,R/S,S configured, which points to a carrier-mediated mode of action. [threo-1,2-Diamino-1-(4-fluorophenyl)propan]dichloridoplatinum(II) and [threo-2,3-diamino-3-(4-fluorophenyl)propan-1-ol]dichloridoplatinum(II) possessed only low cross-resistance to cisplatin and were up to 10-fold more active in lymphoma cell lines.

Synthesis method of selenium-containing isochroman compound

The invention discloses a synthesis method of a selenium-containing isochroman compound. The synthesis method comprises the following steps: under the protection of nitrogen, adding N-phenylseleno saccharin (NPSSac) into a reactor, then adding dichloromethane to completely dissolve the N-phenylseleno saccharin, adding a 1-[(cinnamoxy) methyl]-3, 4, 5-trimethoxy benzene compound and boron trifluoride diethyl etherate after the N-phenylseleno saccharin is completely dissolved, stirring at 20-60 DEG C for 2-6 hours until the reaction is complete, and after the reaction is finished, quenching, extracting, combining organic phases, drying, concentrating, separating and purifying to obtain the selenium-containing isochroman compound. The synthesis method disclosed by the invention is relatively easy to operate, mild in reaction condition, relatively high in yield, environment-friendly and suitable for large-scale industrial production.

Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2as Sole Reductant

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.