125240-16-6

Basic information

• Product Name: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-fluorophenyl)-
• CAS NO: 125240-16-6
• Molecular Formula: C13H9FN4S
• Molecular Weight: 272.306
• Mol File: 125240-16-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-fluorophenyl)-(125240-16-6)
• EPA Substance Registry System: 4H-Thiopyran-3,5-dicarbonitrile, 2,6-diamino-4-(4-fluorophenyl)-(125240-16-6)

Safety Data

• Hazardous Substances Data: 125240-16-6(Hazardous Substances Data)

Usage

Potential applications

organic synthesis and pharmaceutical research

Composition

thiopyran ring, two cyano groups, fluoro substituted phenyl group, two amino groups
Versatile building block for the synthesis of various organic molecules and potential drug candidates
Unique structure and reactivity make it an interesting target for further investigation and potential applications in the development of new chemical entities

Upstream product

• 107-10-8 propylamine 
• 75-15-0 carbon disulfide 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 132252-86-9 (Z)-2-Cyano-3-(4-fluoro-phenyl)-thioacrylamide 
• 7357-70-2 Cyanothioacetamide 
• 2826-22-4 4-fluorobenzylidenemalononitrile 

Downstream Products

• 125219-59-2 N-methylmorpholinium 6-amino-4-(4-fluorophenyl)-3,5-dicyano-2-pyridinethiolate 
• 319491-32-2 2-(4-chlorobenzoylmethylsulfanyl)-4-(4-fluorophenyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 94833-81-5 4-(4-fluorophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 360567-33-5 4-(4-fluorophenyl)-2-(2-oxo-2H-chromen-3-ylcarbonylmethylsulfanyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile 
• 97579-09-4 5-acetyl-6-methyl-4-(4-fluorophenyl)-3-cyano-2<1H>pyridinethione 
• 94639-17-5 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 89451-46-7 6-phenyl-4-(4-fluorophenyl)-3-cyano-2(1H)-pyridinethione 
• 107752-99-8 2-amino-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 110951-40-1 6-methyl-4-(4-fluorophenyl)-3-cyano-5-ethoxycarbonyl-2(1H)pyridinethione 
• 126985-28-2 C₂₃H₁₈FN₃OS 
• 138914-96-2 C₁₈H₁₆FN₃OS 

Relevant articles and documents

Bis(4-pyridylamino)triazine-stabilized magnetite nanoparticles: preparation, characterization and application as a retrievable catalyst for the green synthesis of 4H-pyran, 4H-thiopyran and 1,4-dihydropyridine derivatives

Synthesis of bis(4-pyridylamino)triazine stabilized on silica-coated nano-Fe3O4 particles, and their feasibility as a reusable heterogeneous basic catalyst are reported. The catalytic performance of this novel material was studied fo

CYCLIZATION OF NITRILES. XXXIII. SYNTHESIS AND STRUCTURE OF 4-ARYL-2,6-DIAMINO-3,5-DICYANOTHIOPYRANS AND THEIR RECYCLIZATION TO 6-AMINO-4-ARYL-3,5-DICYANO-2(1H)-PYRIDINETHIONES

Like the three-component condensation of aromatic aldehydes, malononitrile, and cyanothioacetamide, the reaction of arylidenemalononitriles with cyanothioacetamide and of arylidenecyanothioacetamides with malononitrile leads to the formation of 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans.It was established by x-ray crystallographic investigation that the 4H-thiopyran ring in the obtained compounds has the boat conformation.Under the influence of bases the 4H-thiopyrans readily undergo recyclization to 6-amino-4-aryl-3,5-dicyano-2(1H)-pyridinethiones.