94639-17-5

Basic information

• Product Name: 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile
• Synonyms: 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS NO: 94639-17-5
• Molecular Weight: 244.292
• Mol File: 94639-17-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile(94639-17-5)
• EPA Substance Registry System: 4-(4-Fluoro-phenyl)-6-methyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile(94639-17-5)

Safety Data

• Hazardous Substances Data: 94639-17-5(Hazardous Substances Data)

Upstream product

• 132252-86-9 (Z)-2-Cyano-3-(4-fluoro-phenyl)-thioacrylamide 
• 2826-22-4 4-fluorobenzylidenemalononitrile 
• 67-64-1 acetone 
• 105648-21-3 2,4,4-Tricyano-3-(4-fluoro-phenyl)-but-3-enethioic acid amide 
• 125240-16-6 2,6-diamino-4-(4-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile 
• 138914-96-2 C₁₈H₁₆FN₃OS 
• 1687-47-4 propane-2,2-dithiol 
• 94639-08-4 6-Amino-4-(4-fluoro-phenyl)-2,2-dimethyl-4H-[1,3]dithiine-5-carbonitrile 
• 7357-70-2 Cyanothioacetamide 
• 459-57-4 4-fluorobenzaldehyde 
• 109-77-3 malononitrile 
• 29681-98-9 p-fluorobenzoylacetone 

Downstream Products

• 151079-11-7 3-Amino-4-(4-fluoro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid diethylamide 
• 132602-45-0 3-Amino-4-(4-fluoro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 

Relevant articles and documents

Simple isomer separation of 4,6-disubstituted 2-thioxo-1,2-dihydro-pyridine-3-carbonitriles being formed in the reaction of asymmetrically substituted 1,3-diketones with cyanothioacetamide

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CYCLIZATION OF NITRILES. XXXIV. TRANSFORMATION OF 4-ARYL-2,6-DIAMINO-3,5-DICYANO-4H-THIOPYRANS INTO SUBSTITUTED 4-ARYL-3-CYANO-2(1H)-PYRIDINETHIONES AND 2-AMINO-4-ARYL-7,7-DIMETHYL-5-OXO-3-CYANO-5,6,7,8-TETRAHYDRO-4H-BENZOPYRANS

The reaction of 2,6-diamino-3,5-dicyano-4H-thiopyrans with monocarbonyl and acyclic 1,3-dicarbonyl compounds leads to the elimination of malononitrile and the formation of substituted 4-aryl-3-cyano-2(1H)-pyridinethiones.The reaction with 1,3-cycloalkanediones leads to the elimination of cyanothioacetamide and the formation of 2-amino-4-aryl-3-cyano-4H-benzopyrans.

CYCLIZATION OF NITRILES. XIII. 2,2-DIALKYL-4-AMINO-6-ARYL-5-CYANO-1,3-DITHIA-4-CYCLOHEXENES IN THE SYNTHESIS OF 4-ARYL-3-CYANOPYRIDINE-2(1H)-THIONES AND THEIR HETEROCYCLIC TRANSFORMATION PRODUCTS

2,2-Dialkyl-4-amino-6-aryl-5-cyano-1,3-dithia-4-cyclohexenes were obtained in the reaction of 2,2-propane- and 2,2-butanedithiols with arylidenemalononitrile.As a result of recyclization they formed substituted 4-aryl-3-cyanopyridine-2(1H)-thiones.The synthesized compounds were used in the synthesis of various 3-aminothienopyridines and some of their derivatives.