1252590-76-3

Basic information

• Product Name: 1-(2-bromo-5-methoxybenzyl)-4-methyl-1H-pyrazole
• Synonyms: 1-(2-bromo-5-methoxybenzyl)-4-methyl-1H-pyrazole
• CAS NO: 1252590-76-3
• Molecular Weight: 281.152
• Mol File: 1252590-76-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-5-methoxybenzyl)-4-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-5-methoxybenzyl)-4-methyl-1H-pyrazole(1252590-76-3)
• EPA Substance Registry System: 1-(2-bromo-5-methoxybenzyl)-4-methyl-1H-pyrazole(1252590-76-3)

Safety Data

• Hazardous Substances Data: 1252590-76-3(Hazardous Substances Data)

Upstream product

• 7554-65-6 4-methyl-1H-pyrazole 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 

Relevant articles and documents

Direct synthesis of pyrazolo[5,1-a]isoindoles via intramolecular palladium-catalyzed C-H bond activation

An efficient, direct synthesis of pyrazolo-[5,1-a]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl) pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermolecular C-H bond activation.