125274-43-3

Basic information

• Product Name: Boc-Gly-Ala-Glu(OBzl)-OBzl
• Synonyms: Boc-Gly-Ala-Glu(OBzl)-OBzl
• CAS NO: 125274-43-3
• Molecular Weight: 555.628
• Mol File: 125274-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Gly-Ala-Glu(OBzl)-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Gly-Ala-Glu(OBzl)-OBzl(125274-43-3)
• EPA Substance Registry System: Boc-Gly-Ala-Glu(OBzl)-OBzl(125274-43-3)

Safety Data

• Hazardous Substances Data: 125274-43-3(Hazardous Substances Data)

Upstream product

• 59524-71-9 t-butoxycarbonyl-L-alanyl-L-glutamic acid dibenzyl ester 
• 2768-50-5 dibenzyl L-glutamate 
• 4530-20-5 BOC-glycine 

Downstream Products

• 125274-45-5 Boc-Leu-Cys(Acm)-Gly-Ala-Glu(OBzl)-OBzl 
• 125274-44-4 Boc-Cys(Acm)-Gly-Ala-Glu(OBzl)-OBzl 

Relevant articles and documents

Synthesis of two possible disulfide bonds containing peptide fragments (Cys6-Cys47, Cys48-Cys52 (Type I), and Cys6-Cys48, Cys47-Cys52 (Type II) of H-IGF-I) for the identification of disulfide bond linkage in recombinantly produced H-IGF-I

The primary structure of human IGF-I, except for the disulfide bond system, has been reported by Rinderknecht and Humbel. IGF-I afforded the corresponding characteristic peptide fragments on V8 protease digestion, which contained Cys6, Cys47, Cys48, and Cys52. Two possible fragments, Type I with Cys6-Cys47 and Cys48-Cys52 and Type II with Cys6-Cys48 and Cys47-Cys52 of h-IGF-I(4-9,47-53), were chemically synthesized. The disulfide bond system of IGF-I was unequivocally determined to be the Type-II form along with Cys18-Cys61. Interestingly, the Type-I system was included in the disulfide bond isomer produced as the main by-product in the refolding step on IGF-I synthesis by the recombinant DNA method.