59524-71-9

Basic information

• Product Name: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, bis(phenylmethyl) ester
• CAS NO: 59524-71-9
• Molecular Formula: C27H34N2O7
• Molecular Weight: 498.576
• Mol File: 59524-71-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, bis(phenylmethyl) ester(59524-71-9)
• EPA Substance Registry System: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-, bis(phenylmethyl) ester(59524-71-9)

Safety Data

• Hazardous Substances Data: 59524-71-9(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 146844-02-2 D-glutamic acid dibenzyl ester; hydrochloride 
• 2483-49-0 tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester 
• 69408-26-0 dibenzyl glutamate 
• 617-65-2 Glutamic acid 
• 100-51-6 benzyl alcohol 
• 6893-26-1 D-Glutamic acid 
• 2791-84-6 D-glutamic acid dibenzyl ester p-toluenesufonate salt 
• 104-15-4 toluene-4-sulfonic acid 
• 4561-10-8 L-glutamic acid dibenzyl ester hydrochloride 
• 1073-72-9 4-hydroxythioanisole 
• 637-89-8 4-sulfanylphenol 
• 2768-50-5 dibenzyl L-glutamate 
• 123228-28-4 Boc-Ala-Glu-OH 

Downstream Products

• 87063-91-0 H-Ala-Glu(OBn)-OBn 
• 125274-43-3 Boc-Gly-Ala-Glu(OBzl)-OBzl 
• 125274-44-4 Boc-Cys(Acm)-Gly-Ala-Glu(OBzl)-OBzl 
• 125274-45-5 Boc-Leu-Cys(Acm)-Gly-Ala-Glu(OBzl)-OBzl 
• 87063-93-2 benzyloxycarbonyl-L-tryptophyglycyl-L-alanyl-L-glutamic acid dibenzyl ester 
• 1332360-48-1 dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate 
• 1332360-49-2 dibenzyl (2R)-2-[((2S)-2-{[(5,5-dioxo-5,7,8,9-tetrahydro-5λ6-pyrido[1,2-b][1,2]benzisothiazol-10-yl)carbonyl]amino}propanoyl)amino]pentanedioate 
• 1332360-50-5 dibenzyl (2R)-2-[((2S)-2-{[(5,5-dioxo-2,5-dihydro-3H-5λ6-pyrrolo[1,2-b][1,2]benzisothiazol-1-yl)carbonyl]amino}propanoyl)amino]pentanedioate 
• 1332360-51-6 dibenzyl (2R)-2-{[(2S)-2-({3-[(1H-indol-2-ylcarbonyl)amino]propanoyl}amino)propanoyl]amino}pentanedioate 
• 1332360-52-7 dibenzyl (2R)-2-{[(2S)-2-({2-[(1H-indol-2-ylcarbonyl)amino]acetyl}amino)propanoyl]amino}pentanedioate 
• 1332360-46-9 dibenzyl (2R)-2-[((2S)-2-{[5-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)pentanoyl]amino}propanoyl)amino]pentanedioate 
• 1332360-47-0 dibenzyl (2R)-2-[((2S)-2-{[4-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)butanoyl]amino}propanoyl)amino]pentanedioate 
• 66025-58-9 L-alanyl-D-glutamic acid dibenzyl ester trifluoroacetate 

Relevant articles and documents

Inhibitors for bacterial cell-wall recycling

Gram-negative bacteria have evolved an elaborate process for the recycling of their cell wall, which is initiated in the periplasmic space by the action of lytic transglycosylases. The product of this reaction, β-d-N- acetylglucosamine-(1a?'4)-1,6-anhydro-β-d-N-acetylmuramyl-l- Ala-I-d-Glu-meso-DAP-d-Ala-d-Ala (compound 1), is internalized to begin the recycling events within the cytoplasm. The first step in the cytoplasmic recycling is catalyzed by the NagZ glycosylase, which cleaves in a hydrolytic reaction the N-acetylglucosamine glycosidic bond of metabolite 1. The reactions catalyzed by both the lytic glycosylases and NagZ are believed to involve oxocarbenium transition species. We describe herein the synthesis and evaluation of four iminosaccharides as possible mimetics of the oxocarbenium species, and we disclose one as a potent (compound 3, Ki = 300 A± 15 nM) competitive inhibitor of NagZ.

Peptide Synthesis in Aqueous Solution. V. Properties and Reactivities of (p-Hydroxyphenyl)benzylmethylsulfonium Salts for Direct Benzyl Esterification of N-Acylpeptides

Some (p-hydroxyphenyl)benzylmethylsulfonium salts were prepared. These compounds generated a benzyl cation and converted not only N-acylamino acids but also N-acylpeptides into their corresponding benzyl esters without causing the racemization.

A Proton N.M.R. Study of the Conformation of Trp-Gly-Ala-Glu in Dimethyl Sulfoxide and Water

Proton nuclear magnetic resonance parameters are reported for Trp-Gly-Ala-Glu, constituting residues 115-118 of bovine myelin basic protein, in dimethyl sulfoxide solution.The 3JNH,α vicinal coupling constants which were used to dete