125345-26-8

Basic information

• Product Name: 1-hexynyl-2-(methoxymethoxy)benzene
• Synonyms: 1-hexynyl-2-(methoxymethoxy)benzene
• CAS NO: 125345-26-8
• Molecular Weight: 218.296
• Mol File: 125345-26-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-hexynyl-2-(methoxymethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hexynyl-2-(methoxymethoxy)benzene(125345-26-8)
• EPA Substance Registry System: 1-hexynyl-2-(methoxymethoxy)benzene(125345-26-8)

Safety Data

• Hazardous Substances Data: 125345-26-8(Hazardous Substances Data)

Upstream product

• 80778-47-8 1-iodo-2-methoxymethoxybenzene 
• 693-02-7 hex-1-yne 
• 533-58-4 2-Iodophenol 

Downstream Products

• 4265-27-4 2-n-butylbenzo[b]furan 
• 1396511-05-9 methyl (E)-3-(2-(hex-1-ynyl)phenoxy)acrylate 
• 1332460-66-8 1-(1-hexynyl)-2-(2-methylallyloxy)benzene 
• 66898-41-7 3-butyl-2H-chromen-2-one 
• 125345-27-9 2-(hex-1-yn-1-yl)phenol 

Relevant articles and documents

Gold-Catalyzed Domino Synthesis of Functionalized Benzofurans and Tetracyclic Isochromans via Formal Carboalkoxylation

A domino synthesis of benzofurans with the modification of side chains from α-alkoxyalkyl o-alkynylaryl ethers (n = 0) and electron-rich arenes has been developed. In the present domino reaction, which would proceed via the α-alkoxyalkylation of arenes with an intermediate in the migratory cycloisomerization of o-alkynylaryl ethers followed by the nucleophilic addition of benzofurans to benzyl ethers, a cationic Au(III) catalyst activates the C-C π bond and the C-O σ bond. The present method could be extended to Au(I)-catalyzed domino synthesis of tetracyclic isochromans from α-alkoxyalkyl (o-alkynylaryl)methyl ethers (n = 1) and aryl methoxymethyl ethers.

Gold-catalyzed cyclizations of (o-alkynyl)phenoxyacrylates with external nucleophiles: Regio-and stereoselective synthesis of functionalized benzo[b]oxepines

A catalytic approach to benzo[b]oxepines with high stereoselectivity by Au-catalyzed cyclization of (o-alkynyl)phenoxyacrylates with various nucleophiles under mild reaction conditions has been developed. Notably, the use of vinyl ether instead of alcohol could afford the same benzoxepines. The reaction may proceed by Au-catalyzed oligomerization of vinyl ether to release the alcohol, which then reacts with (o-alkynyl)phenoxyacrylates to furnish the benzoxepines.

Rhodium-catalysed cyclic carbonylation of 2-alkynylphenols: Synthesis of benzofuranones and coumarins

Rhodium-catalysed carbonylation of 2-alkynylphenols 1 under water-gas shift reaction conditions gives benzofuranone derivatives 2 and coumarin derivatives 3 in high yield (up to 96%, 2:3 = 65:35), in which the hydroxy group adjacent to the carbon-carbon triple bond participitates in the cyclic carbonylation.