1253646-05-7Relevant articles and documents
The enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8] naphthyridin-2-one
Londregan, Allyn T.,Bernhardson, David,Bradow, James,Makowski, Teresa M.,Storer, Gregory,Warmus, Joseph,Wooten, Ceshea,Yang, Xiaojing
, p. 2072 - 2075 (2010)
A number of approaches to the enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8]naphthyridin-2-one were studied. A novel one-pot asymmetric reduction/lactamization provided the desired products in high yield and enantiomeric excess.