1254211-28-3

Basic information

• Product Name: ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate
• Synonyms: ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate
• CAS NO: 1254211-28-3
• Molecular Weight: 472.379
• Mol File: 1254211-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate(1254211-28-3)
• EPA Substance Registry System: ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate(1254211-28-3)

Safety Data

• Hazardous Substances Data: 1254211-28-3(Hazardous Substances Data)

Upstream product

• 1254211-19-2 ethyl 5-methyl-4-phenyl-1H-pyrrole-3-carboxylate 
• 1254210-99-5 2-bromo-4,5-dimethoxyphenethyl-4-methylbenzenesulfonate 

Downstream Products

• 79823-24-8 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester 

Relevant articles and documents

Synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines featuring an intramolecular radical-oxidative cyclization of polysubstituted pyrroles, and evaluation of their cytotoxic activity

A three-step protocol for the synthesis of 1,2,3,8,9-pentasubstituted-5,6- dihydropyrrolo[2,1-a]isoquinolines is described, using van LeuseN′s polysubstituted pyrrole construction followed by intramolecular radical-oxidative cyclization of the isoquinoline system. The cytotoxic activities of the dihydropyrroloisoquinolines were tested on six tumor cell lines. Preliminary structure-activity studies revealed the importance of the identity of the aromatic substituent at the C-2 position, particularly a phenyl, m-(amino) phenyl or m-(cyclohexylmethylpiperazinamide) phenyl substituent, for cytotoxic activity.