79823-24-8

Basic information

• Product Name: 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester
• Synonyms: 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester
• CAS NO: 79823-24-8
• Molecular Weight: 391.467
• Mol File: 79823-24-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester(79823-24-8)
• EPA Substance Registry System: 5,6-Dihydro-8,9-dimethoxy-3-methyl-2-phenylpyrrolo<2,1-a>isochinolin-1-carbonsaeure-ethylester(79823-24-8)

Safety Data

• Hazardous Substances Data: 79823-24-8(Hazardous Substances Data)

Upstream product

• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 40129-54-2 (6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-ylidene)-acetic acid ethyl ester 
• 1254211-28-3 ethyl 1-(2-bromo-4,5-dimethoxyphenethyl)-5-methyl-4-phenyl-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines featuring an intramolecular radical-oxidative cyclization of polysubstituted pyrroles, and evaluation of their cytotoxic activity

A three-step protocol for the synthesis of 1,2,3,8,9-pentasubstituted-5,6- dihydropyrrolo[2,1-a]isoquinolines is described, using van LeuseN′s polysubstituted pyrrole construction followed by intramolecular radical-oxidative cyclization of the isoquinoline system. The cytotoxic activities of the dihydropyrroloisoquinolines were tested on six tumor cell lines. Preliminary structure-activity studies revealed the importance of the identity of the aromatic substituent at the C-2 position, particularly a phenyl, m-(amino) phenyl or m-(cyclohexylmethylpiperazinamide) phenyl substituent, for cytotoxic activity.