1254566-59-0

Basic information

• Product Name: 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide
• Synonyms: 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide
• CAS NO: 1254566-59-0
• Molecular Weight: 527.552
• Mol File: 1254566-59-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide(1254566-59-0)
• EPA Substance Registry System: 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide(1254566-59-0)

Safety Data

• Hazardous Substances Data: 1254566-59-0(Hazardous Substances Data)

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 918523-58-7 N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide 
• 1254567-60-6 5-(1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridine-2-carboxylic acid ethylamide 
• 918523-57-6 N-(3,5-difluorophenyl)propane-1-sulfonamide 
• 845305-88-6 5-bromo-pyridine-2-carboxylic acid ethylamide 
• 30766-11-1 5-bromoisonicotinic acid 
• 1254566-58-9 5-(3-{[2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-hydroxy-methyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridine-2-carboxylic acid ethylamide 

Relevant articles and documents

PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.