918523-57-6

Basic information

• Product Name: N-(2,4-difluorophenyl)propane-1-sulfonaMide
• Synonyms: N-(2,4-difluorophenyl)propane-1-sulfonaMide
• CAS NO: 918523-57-6
• Molecular Formula: C₉H₁₁F₂NO₂S
• Molecular Weight: 235
• Mol File: 918523-57-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,4-difluorophenyl)propane-1-sulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-difluorophenyl)propane-1-sulfonaMide(918523-57-6)
• EPA Substance Registry System: N-(2,4-difluorophenyl)propane-1-sulfonaMide(918523-57-6)

Safety Data

• Hazardous Substances Data: 918523-57-6(Hazardous Substances Data)

Usage

General Description

N-(2,4-difluorophenyl)propane-1-sulfonamide is a chemical compound that belongs to the sulfonamide class. It is also known by its systematic IUPAC name 2,4-difluoro-N-(propan-2-yl)benzenesulfonamide. N-(2,4-difluorophenyl)propane-1-sulfonamide is commonly used in the pharmaceutical industry as it possesses antibacterial and antimicrobial properties. It works by inhibiting the synthesis of dihydrofolic acid in bacteria, leading to the prevention of the production of essential nucleic acids. This makes it an effective tool in the treatment of a variety of bacterial infections. N-(2,4-difluorophenyl)propane-1-sulfonamide is a valuable chemical that plays a significant role in the development of new antibiotics and the treatment of infectious diseases.

Upstream product

• 10147-36-1 n-propanesulfonyl chloride 
• 367-25-9 2,4-difluorophenylamine 

Downstream Products

• 918523-58-7 N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide 
• 1029872-54-5 vemurafenib 
• 1021854-28-3 N-(3-((5-chloro-1H-pyrrolo[2,3-b]pyridine-3-yl)(hydroxyl)methyl)2,4-difluorophenyl)propane-1-sulfonamide 
• 918505-84-7 N-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonoamide 
• 1254566-58-9 5-(3-{[2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-hydroxy-methyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridine-2-carboxylic acid ethylamide 
• 1254566-59-0 5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide 

Relevant articles and documents

Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research

We report dramatically improved total syntheses of two highly selective V600EBRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without compromising yield. In addition to providing a gram-scale route to these compounds for preclinical oncology research, we anticipate this approach could accelerate the synthesis of azaindoles in high-throughput, library-based formats.

PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.

PYRROLO [2,3-B] PYRIDINES AS KINASE MODULATORS

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.