1255942-08-5 Usage
Description
DBCO-PEG4-amine, also known as DBCO-NHCO-PEG4-amine, is a carboxyl-reactive building block featuring an extended PEG (polyethylene glycol) spacer arm. This molecule is designed to enhance water solubility and facilitate stable amide bond formation with carboxyl groups or activated esters, such as NHS esters, in the presence of activators like EDC or HATU. The DBCO moiety is particularly noteworthy as it is commonly utilized in copper-free Click Chemistry reactions, allowing for efficient and selective bioconjugation processes.
Uses
Used in Bioconjugation:
DBCO-PEG4-amine is used as a bioconjugation agent for the formation of stable amide bonds with carboxyl groups or activated esters. Its extended PEG spacer arm improves the water solubility of the resulting conjugates, which is crucial for applications in aqueous environments.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DBCO-PEG4-amine is used as a component in the development of drug delivery systems. The hydrophilic PEG spacer arm can help improve the solubility and bioavailability of drugs, potentially enhancing their therapeutic efficacy.
Used in Diagnostics:
DBCO-PEG4-amine can be employed in the creation of diagnostic tools, where its ability to form stable amide bonds with target molecules can be leveraged for the detection and analysis of various biomarkers.
Used in Materials Science:
In the field of materials science, DBCO-PEG4-amine can be utilized for the synthesis of functional materials with tailored properties. The PEG spacer arm can contribute to improved hydrophilicity, while the DBCO group enables efficient and selective Click Chemistry reactions for the assembly of complex structures.
Used in Research and Development:
DBCO-PEG4-amine is also valuable in research and development settings, where its reactivity and PEGylation capabilities can be harnessed for the creation of novel bioconjugates and the study of their properties and interactions with biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1255942-08-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,9,4 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1255942-08:
(9*1)+(8*2)+(7*5)+(6*5)+(5*9)+(4*4)+(3*2)+(2*0)+(1*8)=165
165 % 10 = 5
So 1255942-08-5 is a valid CAS Registry Number.
1255942-08-5Relevant articles and documents
AZA-DIBENZOCYCLOOCTYNES AND METHODS OF MAKING AND USING SAME
-
Page/Page column 7-8, (2012/02/06)
Convenient methods of preparing aza-dibenzocyclooctynes are disclosed herein. Aza-dibenzocyclooctynes attached to a surface are also disclosed herein. Aza-dibenzocyclooctynes can be reacted with azides to form heterocyclic compounds. Such reactions can be useful in a wide variety of applications including, for example, labeling surfaces.
