1255942-06-3 Usage
Description
Dibenzocyclooctyne-aMine for Copper-free Click CheMistry, also known as DBCO-amine, is a simple building block containing a DBCO moiety that can be used to incorporate ADIBO into organic compounds, surfaces, or particles. It is a carbonyl reactive reagent that is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions, reacting with azide functionalized compounds or bimolecules to give stable triazole linkage without the need for a Cu(I) catalyst. DBCO-amine can be used to derivatize carboxyl groups or activated esters through a stable amide bond in the presence of activators such as EDC or HATU.
Uses
Used in Chemical Biology and Materials Science:
DBCO-amine is used as a building block for copper-free Click Chemistry reactions, allowing for the efficient and specific conjugation of biomolecules, polymers, and nanoparticles for various applications in chemical biology and materials science.
Used in Bioorthogonal Chemistry:
DBCO-amine is used as a reactive handle for bioorthogonal chemistry, enabling the selective labeling and manipulation of biomolecules within complex biological systems without interfering with native chemistry.
Used in Drug Delivery Systems:
DBCO-amine is used as a functional group for the development of drug delivery systems, allowing for the targeted delivery of therapeutic agents to specific cells or tissues.
Used in Cell Biology:
DBCO-amine is used as a tool for the study of cell surface proteins and other biomolecules, enabling the investigation of their function and interactions within cellular systems.
Used in Medical Research:
DBCO-amine was useful for the study of labeled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy, a promising approach for the treatment of various diseases, including cancer and autoimmune disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 1255942-06-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,9,4 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1255942-06:
(9*1)+(8*2)+(7*5)+(6*5)+(5*9)+(4*4)+(3*2)+(2*0)+(1*6)=163
163 % 10 = 3
So 1255942-06-3 is a valid CAS Registry Number.
1255942-06-3Relevant articles and documents
NUCLEOTIDE DERIVATIVES AND METHODS OF USE THEREOF
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Paragraph 1322, (2017/12/29)
Disclosed herein, inter alia, are compounds, compositions, and methods of thereof in the sequencing a nucleic acid.
Surface functionalization using catalyst-free azide-alkyne cycloaddition
Kuzmin, Alexander,Poloukhtine, Andrei,Wolfert, Margreet A.,Popik, Vladimir V.
, p. 2076 - 2085 (2011/07/09)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged substrates via a copper-free click reaction. Alternatively, ADIBO-conjugated molecules are anchored to the azide-derivatized surface. Both immobilization techniques work well in aqueous solutions and show excellent kinetics under ambient conditions. We report an efficient synthesis of aza-dibenzocyclooctyne (ADIBO), thus far the most reactive cyclooctyne in cycloaddition to azides. We also describe convenient methods for the conjugation of ADIBO with a variety of molecules directly or via a PEG linker.
