1256345-60-4 Usage
Description
2-Fluoro-6-hydroxyphenylboronic acid is an organic compound with the molecular formula C6H6BFO3. It is a synthetic reagent known for its unique properties, which make it valuable in various chemical and pharmaceutical applications. 2-Fluoro-6-hydroxyphenylboronic acid features a boron atom bonded to a phenyl ring, with a fluorine atom at the 2nd position and a hydroxyl group at the 6th position, providing it with specific reactivity and selectivity in chemical reactions.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-6-hydroxyphenylboronic acid is used as a synthetic reagent for the preparation of alkylene-bridged derivatives, which have potential applications as HIV integrase inhibitors. These derivatives, such as [(3,4-dihydro-2H-benzo[b][1,4]oxazinyl) or (piperidinyl)(biphenyl-3-yl)pyrazolo[1,5-a]pyrimidinyl](tert-butoxy)acetic acid, are being developed for the treatment of HIV infection. The compound plays a crucial role in the synthesis of these potential therapeutic agents, contributing to the development of new treatments for HIV.
Check Digit Verification of cas no
The CAS Registry Mumber 1256345-60-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,6,3,4 and 5 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1256345-60:
(9*1)+(8*2)+(7*5)+(6*6)+(5*3)+(4*4)+(3*5)+(2*6)+(1*0)=154
154 % 10 = 4
So 1256345-60-4 is a valid CAS Registry Number.
1256345-60-4Relevant articles and documents
Rh/Pd catalysis with chiral and achiral ligands: Domino synthesis of aza-dihydrodibenzoxepines
Friedman, Adam A.,Panteleev, Jane,Tsoung, Jennifer,Huynh, Vaizanne,Lautens, Mark
, p. 9755 - 9758 (2013)
A game of dominoes: A synthetic route to aza-dihydrodibenzoxepines is described, through the combination of a Rh-catalyzed arylation and a Pd-catalyzed C-O coupling in a single pot. For the first time, the ability to incorporate a chiral and an achiral ligand in a two-component, two-metal transformation is achieved, giving the products in moderate to good yields, with excellent enantioselectivities. Copyright
IMPROVED SYNTHESIS OF KEY INTERMEDIATE OF KRAS G12C INHIBITOR COMPOUND
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Page/Page column 71-72, (2020/06/05)
The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure (I), useful for the synthesis of compounds that target KRAS G12C mutations, such as (II).
Method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid
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Paragraph 0008; 0023; 0024, (2020/06/17)
The invention belongs to the field of synthesis of pharmaceutical compounds, and provides a method for synthesizing 2-fluoro-6-hydroxyphenylboronic acid. The method comprises the following two steps:1) synthesizing an intermediate: reacting 3-fluorophenol
