1259330-61-4Relevant articles and documents
A New Process for the Total Synthesis of Sparstolonin B
Tang, Xiaohang,Tong, Le,Yao, Mengyi,Liang, Qiaoli,Wang, Xiaolong,Yu, Haitao
, p. 1187 - 1190 (2017)
A novel and simple route was developed that gives sparstolonin B in high yields from affordable commercial compounds. A Diels-Alder strategy was used for the facile construction of the multisubstituted diphenyl ether. The xanthenone segment was obtained by cyclization in an intramolecular Friedel-Crafts reaction, followed by selective reduction of a ketone group and a transformation from a hydroxy group into a cyano group. The final part of the lactone was directly derived by the reduction of the cyano group with Raney nickel.
Total synthesis of sparstolonin B via a palladium-catalyzed aldehyde α-arylation
Kim, Dalton,Nash, Aaron,De Brabander, Jef,Tambar, Uttam K.
, p. 3787 - 3790 (2018)
A concise and convergent total synthesis of sparstolonin B was developed. A palladium-catalyzed aldehyde α-arylation was utilized to construct the carbon skeleton of the natural product. A subsequent simple one-pot procedure effected global deprotection and closure of the final two rings via an unusual autoredox mechanism for the conversion of a bis-hydroquinone intermediate to the natural product. The 6 step synthetic sequence was realized in 18% overall yield.
