33567-62-3Relevant articles and documents
Total synthesis of sparstolonin B via a palladium-catalyzed aldehyde α-arylation
Kim, Dalton,Nash, Aaron,De Brabander, Jef,Tambar, Uttam K.
, p. 3787 - 3790 (2018/05/24)
A concise and convergent total synthesis of sparstolonin B was developed. A palladium-catalyzed aldehyde α-arylation was utilized to construct the carbon skeleton of the natural product. A subsequent simple one-pot procedure effected global deprotection and closure of the final two rings via an unusual autoredox mechanism for the conversion of a bis-hydroquinone intermediate to the natural product. The 6 step synthetic sequence was realized in 18% overall yield.
Synthetic and crystallographic studies of a new inhibitor series targeting Bacillus anthracis dihydrofolate reductase
Beierlein, Jennifer M.,Frey, Kathleen M.,Bolstad, David B.,Pelphrey, Phillip M.,Joska, Tammy M.,Smith, Adrienne E.,Priestley, Nigel D.,Wright, Dennis L.,Anderson, Amy C.
experimental part, p. 7532 - 7540 (2009/12/07)
Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism. Baci
SYNTHESIS OF ERBSTATIN
Deshmukh, M. N.,Joshi, Shreerang V.
, p. 1483 - 1490 (2007/10/02)
A simple and convenient synthesis of the tyrosinespecific protein kinase inhibitor, erbstatin (1) from cheap and easily accessible 4-methoxyphenol is described.