1399639-06-5Relevant articles and documents
Synthesis of the tetracyclic core (ABCE rings) of daphenylline
Fang, Bowen,Zheng, Huaiji,Zhao, Changgui,Jing, Peng,Li, Huilin,Xie, Xingang,She, Xuegong
, p. 8367 - 8373,7 (2020/10/15)
A concise synthesis of the tetracyclic core (ABCE rings) of daphenylline has been accomplished involving a benzobicyclo[3.3.1] lactam as the key intermediate. This bridged bicyclic intermediate was efficiently constructed via a Bronsted acid promoted intramolecular Friedel-Crafts type Michael addition of a δ-benzyl α,β-unsaturated δ-lactam.