1259992-51-2

Basic information

• Product Name: C₆H₄FCOSNHCOC₆H₅
• Synonyms: C₆H₄FCOSNHCOC₆H₅
• CAS NO: 1259992-51-2
• Molecular Weight: 275.303
• Mol File: 1259992-51-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₆H₄FCOSNHCOC₆H₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₄FCOSNHCOC₆H₅(1259992-51-2)
• EPA Substance Registry System: C₆H₄FCOSNHCOC₆H₅(1259992-51-2)

Safety Data

• Hazardous Substances Data: 1259992-51-2(Hazardous Substances Data)

Upstream product

• 403-44-1 4-fluorobenzenecarbothioic S-acid 
• 93-97-0 benzoic acid anhydride 
• 1571113-48-8 S-(4-fluorobenzoyl)thiohydroxylamine 

Downstream Products

• 7783-06-4 hydrogen sulfide 

Relevant articles and documents

Cysteine-activated hydrogen sulfide (H2S) donors

H2S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H2S has been hindered by the lack of controllable H2S donors that could mimic the slow and continuous H2S generation process in vivo. Herein we report a series of cysteine-activated H2S donors. Structural modifications of these molecules can regulate the rates of H2S generation. These compounds can be useful tools in H2S research.

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors

Hydrogen sulfide (H2S) is a signaling molecule which plays regulatory roles in many physiological and/or pathological processes. Therefore, regulation of H2S levels could have great potential therapeutic value. In this work, we report the design, synthesis, and evaluation of a class of N-mercapto (N-SH)-based H2S donors. Thirty-three donors were synthesized and tested. Our results indicated that controllable H2S release from these donors could be achieved upon structural modifications. Selected donors (NSHD-1, NSHD-2, and NSHD-6) were tested in cellular models of oxidative damage and showed significant cytoprotective effects. Moreover, NSHD-1 and NSHD-2 were also found to exhibit potent protective effects in a murine model of myocardial ischemia reperfusion (MI/R) injury.