1260667-96-6

Basic information

• Product Name: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one
• Synonyms: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one
• CAS NO: 1260667-96-6
• Molecular Weight: 290.721
• Mol File: 1260667-96-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one(1260667-96-6)
• EPA Substance Registry System: (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one(1260667-96-6)

Safety Data

• Hazardous Substances Data: 1260667-96-6(Hazardous Substances Data)

Upstream product

• 54963-43-8 4-chloro-3-methylphenyl acetate 
• 28480-70-8 5'-chloro-2'-hydroxy-4'-methyl acetophenone 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1260668-02-7 3,6-dichloro-2-(4-fluorophenyl)-7-methyl-4H-chromen-4-one 
• 1260668-12-9 4-chloro-2-((E)-2-(4-fluorophenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4-yl)-5-methylphenol 

Relevant articles and documents

Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives

New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus Niger). Compounds 8a, 8e, 9a, 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.

Synthesis of some biologically important fluorinated 3-chlorochromones and 1,5 - Benzothiazepines as antimicrobial and antifungal agents

A series of synthetic 3-chlorochromones and 1,5-benzo-thiazepines have been synthesized and evaluated for their antimicrobial and antifungal activity against Gram +ve and Gram -ve microorganisms. In these series the chemical transformation of chalcones to