54963-43-8

Basic information

• Product Name: Phenol, 4-chloro-3-methyl-, acetate
• CAS NO: 54963-43-8
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Mol File: 54963-43-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Phenol, 4-chloro-3-methyl-, acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-chloro-3-methyl-, acetate(54963-43-8)
• EPA Substance Registry System: Phenol, 4-chloro-3-methyl-, acetate(54963-43-8)

Safety Data

• Hazardous Substances Data: 54963-43-8(Hazardous Substances Data)

Usage

General Description

4-chloro-3-methylphenol acetate is a chemical compound with the molecular formula C8H7ClO2. It is a derivative of phenol, and is commonly used as a fragrance ingredient and flavoring agent in the production of various consumer products. This chemical compound is also used in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is considered to have low toxicity, but prolonged exposure or high concentrations of 4-chloro-3-methylphenol acetate can have harmful effects on human health and the environment. Therefore, safe handling and proper disposal measures should be followed when working with this chemical.

Upstream product

• 59-50-7 4-Chloro-3-methylphenol 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 

Downstream Products

• 165612-80-6 C₁₆H₁₂ClFO₂ 
• 1260667-96-6 (E)-1-(5-chloro-2-hydroxy-4-methylphenyl)-3-(4-fluorophenyl)prop-2-en-1-one 
• 1355198-80-9 2-hydroxy-5-chloro-4-methylacetophenone isonicotinoylhydrazone 
• 1214728-71-8 C₁₇H₂₄ClNO₅ 
• 63778-54-1 3-(bromomethyl)-4-chlorophenyl acetate 

Relevant articles and documents

Ultrasound-assisted synthesis and antimicrobial activity of tetrazole-based pyrazole and pyrimidine derivatives

New tetrazole-based pyrazole and pyrimidine derivatives were synthesized by an ultrasound irradiation method. All compounds were characterized by infrared spectroscopy (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectrometry (MS) and elemental analysis and assessed in vitro for their efficacy as antimicrobial agents against four bacteria (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa) and two fungi (Candida albicans, Aspergillus Niger). Compounds 8a, 8e, 9a, 9b and 9e show potent activity against the tested strains compared to the reference drugs chloramphenicol and clotrimazole.

Synthesis, antimicrobial activity and anti-biofilm activity of novel tetrazole derivatives

In the development of antimicrobial agents, we designed and synthesized novel tetrazole derivatives. The structures of compounds 6a-f and 7a-f were characterized by IR, 1H NMR, 13C NMR, MS and elemental analysis. These compounds were tested for their antimicrobial activity against a series of strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and for antifungal activity against the strains Candida albicans, Candida glabrata, and Candida tropicalis. Compounds 6e, 6f, 7a, and 7f exhibit potent antimicrobial activities compared to the reference drugs streptomycin and miconazole. Tetrazole derivatives 7a-f also inhibit biofilm formation and compound 7f exhibits best anti-biofilm activity with a biofilm inhibitory concentration (BIC) as low as 0.9 μm.

A new ferrocene-based bulky pyridine as an efficient reusable homogeneous catalyst

An effective approach to reusing a homogeneous catalyst has been demonstrated. A ferrocene-based bulky pyridine has been synthesized and utilized as a homogeneous catalyst for the synthesis of benzoylfumarates as well as for acetylation. After the reaction, the catalyst was separated by simple precipitation and reused without appreciable loss of activity. The Royal Society of Chemistry 2013.