126362-85-4

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-, ethyl ester
• CAS NO: 126362-85-4
• Molecular Formula: C18H12ClFN2O5
• Molecular Weight: 390.755
• Mol File: 126362-85-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-, ethyl ester(126362-85-4)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-, ethyl ester(126362-85-4)

Safety Data

• Hazardous Substances Data: 126362-85-4(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 86483-51-4 ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate 
• 104600-41-1 3-(2,4-dichloro-5-fluorophenyl)-3-oxo-2-ethoxymethylenepropanoic acid ethyl ester 
• 75073-15-3 ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 
• 139396-15-9 (Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(4-nitro-phenylamino)-acrylic acid ethyl ester 

Downstream Products

• 102855-98-1 1-(4-aminophenyl)-6-fluoro-1,4-dihydro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
• 126362-91-2 A 60916 
• 98105-79-4 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 139396-27-3 6-Fluoro-7-(3-methyl-piperidin-1-yl)-1-(4-nitro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 
• 139396-25-1 6-Fluoro-1-(4-nitro-phenyl)-4-oxo-7-pyrrolidin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid 
• 126362-89-8 6-fluoro-1,4-dihydro-7-(4-methylpiperazin-1-yl)-1-(4-nitrophenyl)-4-oxoquinoline-3-carboxylic acid 
• 126362-88-7 1-(4-nitrophenyl)-6-fluoro-7-(1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 126362-87-6 7-Chloro-1-(4-nitrophenyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid 
• 126362-90-1 1-(4-Aminophenyl)-7-chloro-6-fluoro-4-oxoquinoline-3-carboxylic Acid 

Relevant articles and documents

Syntheses and biological activities of new N1-aryl substituted quinolone antibacterials

A series of quinolones with a systematically varied substitution at the phenyl ring at N1 has been synthesized. Three lipophilicity descriptors (log K, log P, R(m)) and the pK(a) values have been determined as well as the microbiological activity: The MIC

SYNTHESIS OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR ANTIBACTERIAL ACTIVITY

1,4-Dihydro-4-oxoquinoline-3-carboxylic acids VIIIc and VIIId were prepared via their ethyl esters VIIIa and VIIIb, which were obtained by a direct arylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (VIa).When treated with piperazine or N-methylpiperazine compound VIIId yields VIIIe or VIIIf, respectively.Reduction of VIIId, VIIIe, and VIIIf with ferrous sulfate yields VIIIg, VIIIh, and VIIIi respectively.Diazotization and introduction of fluorine into VIIIg using hydrogen fluoride-pyridine yields VIIIj.The compounds prepared were testedfor their antimicrobial activity in vitro.