98105-79-4 Usage
Description
1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid, also known as 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, is a 1-arylated derivative of 1,4-dihydro-4-oxoquinoline-3-carboxylic acid. It is a complex organic compound with a unique molecular structure that features a quinoline core, fluorine and chlorine atoms, and a phenyl group. 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid exhibits significant antibacterial properties, making it a promising candidate for pharmaceutical and medical applications.
Uses
Used in Pharmaceutical Industry:
1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid is used as an antibacterial agent for its ability to target and inhibit the growth of various bacteria. Its unique molecular structure allows it to interfere with essential bacterial processes, such as protein synthesis or cell wall synthesis, ultimately leading to the eradication of the bacteria.
Used in Drug Development:
In the field of drug development, 1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid serves as a key intermediate compound in the synthesis of more complex and potent antibacterial drugs. Its chemical properties and reactivity make it an ideal building block for the creation of new and innovative pharmaceuticals to combat antibiotic-resistant bacteria.
Used in Research and Development:
1-(p-Fluoro-phenyl-6-fluoro-7-chloro-4-oxo-3-quinolinecarboxylic acid is also utilized in research and development settings to study the mechanisms of action of antibacterial agents. By understanding how this compound interacts with bacterial cells, researchers can gain insights into the development of new strategies to combat bacterial infections and improve the effectiveness of existing treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 98105-79-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,1,0 and 5 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 98105-79:
(7*9)+(6*8)+(5*1)+(4*0)+(3*5)+(2*7)+(1*9)=154
154 % 10 = 4
So 98105-79-4 is a valid CAS Registry Number.
98105-79-4Relevant articles and documents
Intermediates for producing quinolone-3-carboxylic acids
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, (2008/06/13)
A process for producing a 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid by reacting an acctophenone with a dialkoxycarbonate to obtain the corresponding β-ketoester, treating the β-ketoester with a trialkylorthoformate in the presence of an acid anhydride
SYNTHESIS OF SOME 1-ARYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND THEIR ANTIBACTERIAL ACTIVITY
Radl, Stanislav,Zikan, Viktor
, p. 2181 - 2189 (2007/10/02)
1,4-Dihydro-4-oxoquinoline-3-carboxylic acids VIIIc and VIIId were prepared via their ethyl esters VIIIa and VIIIb, which were obtained by a direct arylation of ethyl 7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (VIa).When treated with piperazine or N-methylpiperazine compound VIIId yields VIIIe or VIIIf, respectively.Reduction of VIIId, VIIIe, and VIIIf with ferrous sulfate yields VIIIg, VIIIh, and VIIIi respectively.Diazotization and introduction of fluorine into VIIIg using hydrogen fluoride-pyridine yields VIIIj.The compounds prepared were testedfor their antimicrobial activity in vitro.
Synthesis and Structure-Activity Relationships of Novel Arylfluoroquinolone Antibacterial Agents
Chu, Daniel T. W.,Fernandes, Prabhavathi B.,Claiborne, Akiyo K.,Pihuleac, Eva,Nordeen, Carl W.,et al.
, p. 1558 - 1564 (2007/10/02)
A series of novel arylfluoroquinolones has been prepared.These derivatives are characterized by having a fluorine atom at the 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.Structure-activity relationship (SAR) studies indicate that the in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or p-hydroxyphenyl and the 7-substituent is either 1-piperazinyl, 4-methyl-1-piperazinyl, or 3-amino-1-pyrrolidinyl.The electronic and spatial properties of the 1-substituent, as well as the steric bulk, play important roles in the antimicrobial potency in this class of antibacterials.As a result of this study, compounds 45 and 41 were found to possess excellent in vitro potency and in vivo efficacy.