126559-85-1

Basic information

• Product Name: 11β-(2-fluoroethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
• Synonyms: 11β-(2-fluoroethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)
• CAS NO: 126559-85-1
• Molecular Weight: 498.681
• Mol File: 126559-85-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 11β-(2-fluoroethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(CAS DataBase Reference)
• NIST Chemistry Reference: 11β-(2-fluoroethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(126559-85-1)
• EPA Substance Registry System: 11β-(2-fluoroethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)(126559-85-1)

Safety Data

• Hazardous Substances Data: 126559-85-1(Hazardous Substances Data)

Upstream product

• 129000-34-6 11β-(1-ethenyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) 
• 129000-33-5 11β-vinylestrone 3-acetate 
• 68599-01-9 11beta-Vinylestradiol 
• 126559-84-0 11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) 

Relevant articles and documents

Synthesis and Estrogen Receptor Binding of Novel 11β-Substituted Estra-1,3,5(10)-triene-3,17β-diols

As part of our program to develop estrogenic radioligands for use in nuclear medicine, a study was undertaken to investigate the effect of substituents on the receptor affinity of putative radiochemicals.In the study a synthetic strategy directed toward the introduction of an 11β-(fluoroethyl) substituent was devised.The target compound 9 was prepared via a five-step procedure starting from 11β-vinylestrone 3-acetate (4) in an overall 43percent yield.The final product and several analogues, 11β-ethyl-, -vinyl-, and (hydroxyethyl)estradiols (11, 5, and 12), were evaluated for their estrogen receptor binding affinity.The results indicate that the target compound and several 11β-substituted analogues possess relative binding affinities greater than of estradiol and its 16α-fluorinated derivatives.The manner in which the target compound 9 was prepared is amenable to use with 18F incorporation.