1266784-04-6

Basic information

• Product Name: (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide
• Synonyms: (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide
• CAS NO: 1266784-04-6
• Molecular Weight: 306.587
• Mol File: 1266784-04-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide(1266784-04-6)
• EPA Substance Registry System: (R)-(+)-N-[1-(3-bromo-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide(1266784-04-6)

Safety Data

• Hazardous Substances Data: 1266784-04-6(Hazardous Substances Data)

Upstream product

• 1213181-85-1 (2R)-2-amino-2-(3-bromophenyl)-propan-1-ol 
• 79-04-9 chloroacetyl chloride 
• 1394137-79-1 (S)-N-((R)-2-(3-bromophenyl)-1-(tert-butyldiphenylsilyloxy)propan-2-yl)-2-methylpropane-2-sulfinamide 
• 1183581-39-6 (RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester 
• 1262858-66-1 rac-N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]-2-chloroacetamide 
• 1183013-69-5 (RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol 

Downstream Products

• 1266785-37-8 (5R)-5-(3-bromophenyl)-5-methyl-morpholin-3-one 
• 1352419-23-8 (5R)-5-(3-bromophenyl)-5-methylmorpholine-3-thione 
• 1352419-24-9 (R)-5-(3-bromophenyl)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1394137-71-3 (R)-5-[3-(benzhydrylideneamino)phenyl]-5-methyl-2,6-dihydro-2H-1,4-oxazin-3-amine 
• 1352419-25-0 (5R)-5-(3-aminophenyl)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine 
• 1266786-47-3 N-{3-[(3R)-5-amino-3-methyl-3,6-dihydro-2H-1,4-oxazin-3-yl]phenyl}-5-chloropyridine-2-carboxamide 

Relevant articles and documents

A practical entry to β-aryl-β-alkyl amino alcohols: Application to the synthesis of a potent BACE1 inhibitor

The 1,2-addition of alkyl Grignard reagents to readily available N-tert-butanesulfinyl ketimines, bearing an α-silyloxy substituent, proceeds in high yields and excellent diastereocontrol. The utility of the present method was demonstrated by the synthesi

3-AMINO-5-PHENYL-5,6-DIHYDRO-2H-[1,4]OXAZINE DERIVATIVES

The present invention relates to 3-Amino-5-phenyl-5,6-dihydro-2H-[l,4]oxazine derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active