1267634-97-8

Basic information

• Product Name: C₂₂H₁₇ClN₄O₂
• CAS NO: 1267634-97-8
• Molecular Weight: 404.856
• Mol File: 1267634-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₇ClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₇ClN₄O₂(1267634-97-8)
• EPA Substance Registry System: C₂₂H₁₇ClN₄O₂(1267634-97-8)

Safety Data

• Hazardous Substances Data: 1267634-97-8(Hazardous Substances Data)

Upstream product

• 22316-55-8 N-desmethylclobazam 
• 61911-86-2 7-chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione 
• 89-63-4 4-Chloro-2-nitroaniline 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 3731-53-1 4-(aminomethyl)pyridine 
• 36985-18-9 8-chloro-3-(dimethylamino-methylene)-1-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione 

Relevant articles and documents

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.