22316-55-8 Usage
Description
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is a chemical compound that belongs to the benzodiazepine class. It is a major active metabolite of clobazam, a controlled substance with depressant effects. 8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is primarily produced by the action of cytochrome P450 isoform 3A4 and is known for its ability to positively modulate GABAA receptors. It is characterized as an off-white solid and is used in various applications, including research and forensic analysis.
Uses
Used in Pharmaceutical Applications:
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is used as an active metabolite for clobazam, a pharmaceutical drug with depressant properties. Its role in modulating GABAA receptors contributes to its therapeutic effects in treating various conditions.
Used in Research Applications:
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is used as an analytical reference material in research settings, particularly for studying the effects and mechanisms of benzodiazepines. It helps researchers understand the interactions between these compounds and GABAA receptors.
Used in Forensic Applications:
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is used as a certified reference material in forensic analysis. It is particularly useful in forensic toxicology and urine drug testing, where it helps in the identification and quantification of clobazam and its metabolites in biological samples.
Used in Drug Testing Applications:
8-Chloro-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione is utilized in drug testing to detect the presence of clobazam and its metabolites in urine, serum, and plasma samples. It aids in the diagnosis of substance abuse and monitoring of therapeutic drug levels in patients undergoing treatment with clobazam.
Check Digit Verification of cas no
The CAS Registry Mumber 22316-55-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,1 and 6 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 22316-55:
(7*2)+(6*2)+(5*3)+(4*1)+(3*6)+(2*5)+(1*5)=78
78 % 10 = 8
So 22316-55-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H11ClN2O2/c16-10-6-7-12-13(8-10)18(11-4-2-1-3-5-11)15(20)9-14(19)17-12/h1-8H,9H2,(H,17,19)
22316-55-8Relevant articles and documents
Method for industrially producing clobazam
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, (2021/05/01)
The invention discloses a method for industrially producing clobazam, and belongs to the technical field of medicine synthesis. According to the method, 5-chloro-2-nitrobenzidine is used as a raw material, and a clobazam bulk drug is prepared through processes of acylation, reduction ring closing, methylation and refining. According to the invention, the problems that reagents with high toxicity are used in the prior art, the pollution is serious, and potential safety hazards exist in the pressurized hydrogenation reaction are solved, the production cost is reduced, and the product quality and economic benefits are improved.
PROCESS FOR PREPARING CLOBAZAM USING NOVEL INTERMEDIATES
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Page/Page column 21, (2016/12/22)
Processes for preparation of 7-chloro-1-methyl-5-phenyl-1,5-dihydro- benzo[b][1,4]diazepine-2,4-dione (Clobazam) are provided. The present invention also relates to the novel intermediates and its use in preparation of clobazam.
Method being suitable for industrially producing clobazam
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, (2017/04/08)
The invention discloses a method of industrially producing clobazam and belongs to the technical field of medicine synthesis. With 5-chloro-2-nitrobenzidine as an initial raw material, the method includes the steps of reduction with a nano heavy metal granular catalyst, catalytic condensation with Lewis acid, methylation, and purification to prepare the clobazam that satisfies clinical medicinal requirement. The method solves the problems of heavy toxicity and serious pollution in the prior art, is beneficial to labor protection and reduces production cost, and improves product quality and economic benefit.
