22316-45-6 Usage
Description
Ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate is an organic compound characterized by its chemical structure that features a phenyl group with a chloro and nitro substitution, attached to an amino group. ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate is a yellow solid and is utilized as a reagent in the synthesis of various chemical compounds.
Uses
Used in Pharmaceutical Industry:
Ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate is used as a reagent for the preparation of substituted Benzodiazepines, which are a class of chemicals with significant applications in the pharmaceutical industry. These benzodiazepines are known for their anxiolytic, sedative, hypnotic, anticonvulsant, muscle relaxant, and amnestic properties, making them valuable in the treatment of various medical conditions such as anxiety, insomnia, and seizures.
Used in Chemical Synthesis:
In the field of chemical synthesis, ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate serves as an important intermediate for the creation of a wide range of chemical products. Its unique structure allows for further functionalization and modification, leading to the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
Due to its structural complexity and reactivity, ethyl 3-[(5-chloro-2-nitrophenyl)phenylamino]-3-oxopropionate is also employed in research and development laboratories. Scientists and researchers use this compound to study its chemical properties, reactivity, and potential applications in the synthesis of novel molecules. This contributes to the advancement of knowledge in organic chemistry and the discovery of new compounds with beneficial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 22316-45-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,1 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 22316-45:
(7*2)+(6*2)+(5*3)+(4*1)+(3*6)+(2*4)+(1*5)=76
76 % 10 = 6
So 22316-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H15ClN2O5/c1-2-25-17(22)11-16(21)19(13-6-4-3-5-7-13)15-10-12(18)8-9-14(15)20(23)24/h3-10H,2,11H2,1H3
22316-45-6Relevant articles and documents
Preparation method of clobazam
-
Paragraph 0027; 0028, (2017/07/23)
The invention provides a preparation method of clobazam. The preparation method comprises the following steps: (1), using 2-nitro-5-chlorodiphenylamine and ethyl malonyl chloride as raw materials, performing a reflow reaction in an organic solvent, after the reaction, decompressing the organic solvent in the reaction system, then performing evaporation to dryness, and adding a refining solvent for refining treatment so as to obtain a compound as shown in a formula II; (2), performing zinc powder reduction on the compound as shown in the formula II, and performing ammonolysis cyclization so as to obtain a compound as shown in a formula III; (3) enabling the compound as shown in the formula III to react with methyl iodide in an alkaline alcohol solution so as to obtain the clobazam, wherein alkali is one or more of sodium hydroxide, lithium hydroxide and potassium hydroxide. The clobazam prepared by the method is few in impurities and high in purity.
SYNTHESIS AND BIOLOGICAL EVALUATION OF 7-CHLORO-1-TRIDEUTERIOMETHYL-5-PHENYL-1H-1,5-BENZODIAZEPINE-2,4(3H,5H)-DIONE (CLOBAZAM-D3)
Poupaert, Jacques H.,Guiot, Pierre,Jacqmin, Philippe,Dumont, Pierre
, p. 417 - 420 (2007/10/02)
Clobazam-d3 has been prepared by treatment of norclobazam sodium salt with trideuteriomethyl iodide.Clobazam-d3 has a pharmacological profile rather similar to that of clobazam.It differs by its longer duration of anti-epileptic action.Keywords - anti-epiliptic action / clobazam-d3
