127088-91-9

Basic information

• Product Name: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate
• Synonyms: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate
• CAS NO: 127088-91-9
• Molecular Weight: 1024.16
• Mol File: 127088-91-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate(127088-91-9)
• EPA Substance Registry System: triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate(127088-91-9)

Safety Data

• Hazardous Substances Data: 127088-91-9(Hazardous Substances Data)

Upstream product

• 128981-11-3 C₃₅H₃₅N₈O₇P 
• 128981-12-4 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate 
• 118149-23-8 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) N,N-diisopropylphosphoramidite 
• 104655-84-7 5‘-O-dimethoxytrityl-2’-deoxyribothymidine 3‘-O-phosphorodiamidite 
• 21090-30-2 3'-O-acetylthymidine 
• 127088-88-4 O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-dimethylthiophosphoramidite 
• 208458-78-0 bis(dimethylamino)-[5'-(4,4'-dimethoxy)trityl-thymid-3'-yl]phosphorodiamidite 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 118149-27-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 118149-25-0 O-5'-O-(Di-p-methoxytrityl)thymidin-3'-yl, O-3'-O-(acetyl)thymidin-5'-yl-phosphorodithioate 
• 121-44-8 triethylamine 
• 118149-24-9 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) hydrogenphosphonothioate 
• 127088-90-8 O-(3'-O-acetylthymidin-5'-yl) O-(5'-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) phosphorodithioate 
• 127088-95-3 C₄₆H₅₀N₅O₁₃PS 

Downstream Products

• 118149-31-8 5'-O-dimethoxytritylthimidine-3'-O-(5'-O-thymidylyl-3'-O-acetyl)phosphorothioate 
• 118149-27-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 

Relevant articles and documents

Solution phase synthesis of dithymidine phosphorodithioate using new S- protecting groups in combination with a chemoselective coupling reagent (PyNOP)

A method for the synthesis of O-thymidin-3'-yl S-alkyl dithiophosphate monomers 1 with different S-protecting groups has been developed. These have been used for solution phase synthesis of dithymidine phosphorodithioate by a new phosphotriester method. C

Synthesis of oligonucleotide phosphorodithioates

The synthesis of DNA containing sulfur at the two nonbonding internucleotide valencies is reported. Several different routes using either tervalent or pentavalent mononucleotide synthons are described.

Deoxyribonucleoside Phosphorodithioates. Preparation of Dinucleoside Phosphorodithioates from Nucleoside Thiophosphoramidites

A series of protected thymidine thiophosphoramidites have been prepared and their properties evaluated.Although less reactive than phosphoramidites, thiophosphoramidites with small N-substituents (methyl) are useful synthons for the preparation of nucleoside phosphorodithioates, as demonstrated by the preparation of a thymidine dimer.The coupling reactions are not as clean as those of the analogous phosphoramidites since the alkylthio group is somewhat labile.