208458-78-0

Basic information

• Product Name: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(tetramethylphosphorodiamidite)
• CAS NO: 208458-78-0
• Molecular Formula: C35H43N4O7P
• Molecular Weight: 662.723
• Mol File: 208458-78-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(tetramethylphosphorodiamidite)(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(tetramethylphosphorodiamidite)(208458-78-0)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-(tetramethylphosphorodiamidite)(208458-78-0)

Safety Data

• Hazardous Substances Data: 208458-78-0(Hazardous Substances Data)

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 1608-26-0 Hexamethylphosphorous triamide 
• 3348-44-5 bis(N,N-dimethylamino)chlorophosphine 

Downstream Products

• 127088-96-4 C₅₀H₅₁Cl₂N₄O₁₃PS 
• 127088-90-8 O-(3'-O-acetylthymidin-5'-yl) O-(5'-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) phosphorodithioate 
• 127088-95-3 C₄₆H₅₀N₅O₁₃PS 
• 118149-25-0 O-5'-O-(Di-p-methoxytrityl)thymidin-3'-yl, O-3'-O-(acetyl)thymidin-5'-yl-phosphorodithioate 
• 127088-91-9 triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 118149-27-2 O-[5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl] S-(2,4-dichlorobenzyl) O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 119619-07-7 C₄₀H₄₃ClN₃O₇PS 
• 119619-08-8 O-(5'-O-(dimethoxytrityl)thymidin-3'-yl) S-(2,4-dichlorobenzyl) N,N-dimethyl thiophosphoramidite 
• 127088-88-4 O-(5'-O-dimethoxytritylthymidin-3'-yl) S-(2-cyanoethyl) N,N-dimethylthiophosphoramidite 

Relevant articles and documents

Synthesis of Oligodeoxynucleoside Phosphorodithioates via Thioamidites

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Deoxyribonucleoside Phosphorodithioates. Preparation of Dinucleoside Phosphorodithioates from Nucleoside Thiophosphoramidites

A series of protected thymidine thiophosphoramidites have been prepared and their properties evaluated.Although less reactive than phosphoramidites, thiophosphoramidites with small N-substituents (methyl) are useful synthons for the preparation of nucleoside phosphorodithioates, as demonstrated by the preparation of a thymidine dimer.The coupling reactions are not as clean as those of the analogous phosphoramidites since the alkylthio group is somewhat labile.