127126-27-6Relevant articles and documents
An efficient synthesis of enantiomerically pure (1R,2S,5S)- and (1S,2R,5R)-rosaprostol methyl esters
Murcia, M. Carmen,De La Herran, Gabriela,Plumet, Joaquín,Csaky, Aurelio G.
, p. 1553 - 1556 (2007)
We report a concise synthesis of the enantiomerically pure 1,2-trans-1,5-cis-methyl esters of rosaprostol, a prostaglandin derivative used for the treatment of gastric and duodenal ulcers, using as key step the chemo- and stereoselective Michael addition of a Grignard reagent to an unprotected hydroxycyclopentenone. Georg Thieme Verlag Stuttgart.
Total synthesis of isoprostanes via the two-component coupling process
Rodríguez, Ana R.,Spur, Bernd W.
, p. 4575 - 4579 (2007/10/03)
A short total synthesis of isoprostanes has been achieved using a two-component coupling process combined with a diastereoselective protonation under reagent control. The F1-isoprostanes were easily obtained by stereoselective reduction of the C-9 keto group.
