41138-61-8 Usage
Description
METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE is a complex organic compound with a specific stereochemistry and functional groups. It is characterized by its molecular structure, which includes a cyclopentene ring, a hydroxyl group, and a ketone group. METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE is of interest in various fields due to its unique properties and potential applications.
Uses
1. Pharmaceutical Industry:
METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE is used as an active pharmaceutical ingredient (API) for the development of drugs targeting specific medical conditions. Its unique structure and functional groups allow for the modulation of biological pathways and interactions with target molecules, making it a promising candidate for therapeutic applications.
2. Synthesis of Other Compounds:
In the field of organic chemistry, METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE can be used as a key intermediate in the synthesis of other complex organic molecules. Its functional groups can be further modified or used as a starting point for the creation of novel compounds with specific properties and applications.
3. Research and Development:
METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE is also used in research and development settings to study its properties, reactivity, and potential applications in various fields. This includes exploring its use in drug discovery, material science, and other areas where novel organic compounds are of interest.
4. Misoprostol Development:
METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE is used as a key component in the development of misoprostol, a medication used for the treatment of peptic ulcer disease. Misoprostol is an ingredient of (+)-norprostol, and its synthesis involves the use of METHYL (R)-(+)-3-HYDROXY-5-OXO-1-CYCLOPENTENE-1-HEPTANOATE as a starting material or intermediate.
Synthesis Reference(s)
Synthesis, p. 781, 1986 DOI: 10.1055/s-1986-31779
Check Digit Verification of cas no
The CAS Registry Mumber 41138-61-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,1,3 and 8 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 41138-61:
(7*4)+(6*1)+(5*1)+(4*3)+(3*8)+(2*6)+(1*1)=88
88 % 10 = 8
So 41138-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H20O4/c1-17-13(16)7-5-3-2-4-6-10-8-11(14)9-12(10)15/h8,11,14H,2-7,9H2,1H3/t11-/m0/s1
41138-61-8Relevant articles and documents
An efficient synthesis of enantiomerically pure (1R,2S,5S)- and (1S,2R,5R)-rosaprostol methyl esters
Murcia, M. Carmen,De La Herran, Gabriela,Plumet, Joaquín,Csaky, Aurelio G.
, p. 1553 - 1556 (2008/02/05)
We report a concise synthesis of the enantiomerically pure 1,2-trans-1,5-cis-methyl esters of rosaprostol, a prostaglandin derivative used for the treatment of gastric and duodenal ulcers, using as key step the chemo- and stereoselective Michael addition of a Grignard reagent to an unprotected hydroxycyclopentenone. Georg Thieme Verlag Stuttgart.
An efficient asymmetric synthesis of prostaglandin E1
Rodriguez, Ana,Nomen, Miguel,Spur, Bernd Werner,Godfroid, Jean-Jacques
, p. 2655 - 2662 (2007/10/03)
An asymmetric total synthesis of Prostaglandin E1 (5) has been achieved in a two-component coupling process. The chiral hydroxycyclopentenone 6 was readily available from furan with 96% ee. The key reaction step was a kinetic enzymatic resolution followed by an in situ inversion. A catalytic asymmetric reduction of the γ-iodo vinyl ketone 19 with the Corey CBS catalyst gave the ω-side chain 7 with >96% ee. Conjugate addition using the reaction with dilithiocyanocuprate followed by mild cleavage of the silyl protective groups and enzymatic hydrolysis of the methyl ester 22 gave (-)-PGE1 5 in high yield.
Production of cyclopentenones
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, (2008/06/13)
A process for preparing an optically active cyclopentenone of the formula: wherein R is a hydrogen atom or a lower alkyl group and n is an integer of 4 to 8, which comprises contacting a dl-cyclo-pentenone ester of the formula: wherein R and n are each as defined above and R′ is a lower alkyl group optionally substituted with halogen on an enzyme having a capability of hydrolyzing selectively either one of the d- or l-form isomer in the dl-cyclopentenone ester (II) in an aqueous medium for asymmetric hydrolysis.
