1272356-73-6Relevant articles and documents
Utilizing Native Directing Groups: Synthesis of a Selective IKur Inhibitor, BMS-919373, via a Regioselective C-H Arylation
Wisniewski, Steven R.,Stevens, Jason M.,Yu, Miao,Fraunhoffer, Kenneth J.,Romero, Evan O.,Savage, Scott A.
, p. 4704 - 4714 (2019/04/30)
BMS-919373 is a highly functionalized quinazoline under investigation as a selective, potent IKur current blocker. By utilizing the aminomethylpyridine side chain at C-4, a selective C-H functionalization at C-5 was invented, enabling the effic