1275621-14-1

Basic information

• Product Name: 1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene
• Synonyms: 1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene
• CAS NO: 1275621-14-1
• Molecular Weight: 233.055
• Mol File: 1275621-14-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene(1275621-14-1)
• EPA Substance Registry System: 1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene(1275621-14-1)

Safety Data

• Hazardous Substances Data: 1275621-14-1(Hazardous Substances Data)

Usage

Structure

1-bromo-4-(2,2-difluorocycloprop-1-yl)benzene
It is a derivative of benzene with a bromine atom at the 1 position and a cyclopropyl group at the 4 position, which is substituted with two fluorine atoms.

Application

Organic synthesis
Used as a building block for the preparation of various pharmaceuticals and agrochemicals.

Application

Research and development
Utilized as a starting material for the synthesis of novel compounds with potential biological activity.

Physical state

Colorless liquid at room temperature
The compound is a liquid and has a colorless appearance under normal conditions.

Reactivity

Handle with care
Due to its reactivity, it should be handled cautiously to avoid any hazardous situations.

Health hazards

Potential health risks
The compound may pose health risks, and appropriate safety measures should be taken when handling it.

Upstream product

• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 1895-39-2 sodium chlorodifluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 115262-00-5 [chloro(difluoro)methyl]trimethylsilane 

Relevant articles and documents

Rhodium Catalyzed Regioselective C?H Allylation of Simple Arenes via C?C Bond Activation of Gem-difluorinated Cyclopropanes

Herein, we report a rhodium catalyzed directing-group free regioselective C?H allylation of simple arenes. Readily available gem-difluorinated cyclopropanes can be employed as highly reactive allyl surrogates via a sequence of C?C and C?F bond activation, providing allyl arene derivatives in good yields with high regioselectivity under mild conditions. The robust methodology enables facile late-stage functionalization of complex bioactive molecules. The high efficiency of this reaction is also demonstrated by the high turnover number (TON, up to 1700) of the rhodium catalyst on gram-scale experiments. Preliminary success on kinetic resolution of this transformation is achieved, providing a promising access to enantio-enriched gem-difluorinated cyclopropanes.

DIFLUOROMETHYLENE COMPOUND AND PRODUCTION METHOD THEREOF

PROBLEM TO BE SOLVED: To provide a difluoromethylene compound useful as a synthetic intermediate of medical and agricultural chemicals and functional materials; and a production method thereof. SOLUTION: The invention provides: a fluorine-containing compound represented by the specified general formula (1); and a production method of the fluorine-containing compound by opening the ring of a difluorocyclopropane represented by the specified general formula (2) in a solvent in the presence of a reagent for introducing X1 and a reagent for introducing X2. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

An improved method for difluorocyclopropanation of alkenes

Difluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances. Georg Thieme Verlag Stuttgart. New York.