1284258-90-7Relevant articles and documents
An efficient enantioselective synthesis of florfenicol via asymmetric aziridination
Wang, Zhonghua,Li, Feng,Zhao, Lei,He, Qiuqin,Chen, Fener,Zheng, Chen
, p. 9199 - 9203 (2011/12/01)
An efficient enantioselective synthesis of florfenicol is accomplished in 44.7% overall yield from commercially available p-(methylsulfonyl)benzaldehyde. Key features of this synthesis are the asymmetric aziridination reaction mediated by the Wulff's catalyst in situ derived from (R)-VANOL and diastereoselectively ring-opening of (2S,3S)-fluoroaziridine 13.