128573-54-6 Usage
Description
(R)-2-HYDROXY-4-PHENYLBUTENOIC ACID, also known as (R)-2-Hydroxy-4-phenylbut-2-enoic acid, is a chiral chemical compound with the molecular formula C10H10O3. It is a key intermediate in the synthesis of various pharmaceuticals and natural products, and has been studied for its potential therapeutic properties. (R)-2-HYDROXY-4-PHENYLBUTENOIC ACID is of interest in the development of new drugs and is also used as a building block in the synthesis of complex organic molecules, which can undergo various chemical reactions to produce different derivatives and analogs with distinct properties and potential applications in medicine and industry.
Uses
Used in Pharmaceutical Research:
(R)-2-HYDROXY-4-PHENYLBUTENOIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals and natural products for [application reason] its potential therapeutic properties and interest in the development of new drugs.
Used in Organic Synthesis:
(R)-2-HYDROXY-4-PHENYLBUTENOIC ACID is used as a building block in the synthesis of complex organic molecules for [application reason] its ability to undergo various chemical reactions to produce different derivatives and analogs with distinct properties and potential applications in medicine and industry.
Used in Medicine:
(R)-2-HYDROXY-4-PHENYLBUTENOIC ACID is used as a compound with potential therapeutic properties for [application reason] its study in the development of new drugs and its potential applications in various medical fields.
Used in Industry:
(R)-2-HYDROXY-4-PHENYLBUTENOIC ACID is used in the industry for the production of different derivatives and analogs with distinct properties for [application reason] its potential applications in various industrial processes and the development of new products.
Check Digit Verification of cas no
The CAS Registry Mumber 128573-54-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,5,7 and 3 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 128573-54:
(8*1)+(7*2)+(6*8)+(5*5)+(4*7)+(3*3)+(2*5)+(1*4)=146
146 % 10 = 6
So 128573-54-6 is a valid CAS Registry Number.
128573-54-6Relevant articles and documents
ENANTIOSELECTIVE REDUCTION OF β,χ-UNSATURATED α-kETO ACIDS USING BACILLUS STEAROTHERMOPHILUS LACTATE DEHYDROGENASE: A NEW ROUTE TO FUNCTIONALISED ALLYLIC ALCOHOLS
Casy, Guy,Lee, Thomas V.,Lovell, Helen
, p. 817 - 820 (1992)
The enantioselective reduction of α-keto acids, catalysed by lactate dehydrogenase, has been extended to β,χ-unsaturated substrates, providing functionalised allylic alcohols in high optical purity.
Method for preparing lisinopril intermediate
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Paragraph 0047; 0049; 0050, (2017/04/03)
The invention provides a method for preparing a lisinopril intermediate. The lisinopril intermediate is (R)-2-hydroxyl-4-phenylbutyrate. The method has the advantages that the lisinopril intermediate is made of inexpensive and easily available raw materials which are benzaldehyde and pyruvic acid, four-step efficient reaction including condensation, biological enzyme catalytic asymmetric reduction, double-bond hydrogenation and esterification is carried out on the benzaldehyde and the pyruvic acid, and accordingly an optically pure target product (R)-HPBE [(R)-2-hydroxyl-4-phenylbutyrate] can be ultimately obtained at the overall yield of 83%.
Direct asymmetric hydrogenation of 2-oxo-4-arylbut-3-enoic acids
Zhu, Lvfeng,Meng, Qinghua,Fan, Weizheng,Xie, Xiaomin,Zhang, Zhaoguo
supporting information; experimental part, p. 6027 - 6030 (2010/11/18)
A challenging direct asymmetric hydrogenation of (E)-2-oxo-4-arylbut-3- enoic acids to give 2-hydroxy-4-arylbutanoic acids (85.4-91.8% ee) was achieved with a Ru catalyst based on SunPhos as the chiral ligand. Further investigation of the reaction revealed that partial isomerization of 2-hydroxy-4-arylbutenoic acids was involved in the hydrogenation process. Employing the reaction conditions to the hydrogenation of 2-oxo-4-phenylbutanoic acid resulted in better enantioselectivity (91.8% ee) and efficiency (TON = 2000, TOF = 200 h-1), which offers a useful method for the synthesis of a common intermediate for ACE inhibitors.
