128612-43-1

Basic information

• Product Name: DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE
• Synonyms: METHYL 5-[5-(METHOXYCARBONYL)PYRIDIN-3-YL]NICOTINATE;DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE;DIMETHYL 5,5'-BIPYRIDINE-3,3'-DICARBOXYLATE;Dimethyl 5,5'-bipyridine-3,3'-dicarboxylate 97%;Dimethyl3,3'-bipyridine-5,5'-dicarboxylate97%
• CAS NO: 128612-43-1
• Molecular Formula: C14H12N2O4
• Molecular Weight: 272.26
• Product Categories: blocks;Carboxes;Pyridines
• Mol File: 128612-43-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 226-230
• Boiling Point: 443.1 °C at 760 mmHg
• Flash Point: 221.8 °C
• Appearance: /
• Density: 1.254 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE(128612-43-1)
• EPA Substance Registry System: DIMETHYL 3,3'-BIPYRIDINE-5,5'-DICARBOXYLATE(128612-43-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 128612-43-1(Hazardous Substances Data)

Usage

Uses

Dimethyl 3,3''-bipyridine-5,5''-dicarboxylate

Upstream product

• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 1025718-91-5 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinecarboxylic acid methyl ester 
• 40473-07-2 6-bromo-2-methoxypyridine 

Relevant articles and documents

A General, Multimetallic Cross-Ullmann Biheteroaryl Synthesis from Heteroaryl Halides and Heteroaryl Triflates

Despite their importance to medicine and materials science, the synthesis of biheteroaryls by cross-coupling remains challenging. We describe here a new, general approach to biheteroaryls: the Ni-and Pd-catalyzed multimetallic cross-Ullmann coupling of he

Total synthesis of (±)-cytisine

(equation presented) The nicotine partial agonist cytisine was prepared in five steps featuring an "in situ" Stille or Suzuki biaryl pyridine coupling. Differentiation of the pyridyl rings was accomplished via selective benzylation and then reduction of a pyridinium ring. The penultimate diazabicyclo[3.3.1]-nonane intermediate was obtained with high diastereoselectivity. A similar sequence has been employed for the synthesis of novel derivative 9-methoxycytisine.