29681-44-5Relevant articles and documents
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Clark
, p. 535,537-539 (1976)
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Total Syntheses and Antimicrobial Activities of Pyridine Alkaloids from Rubiaceae
Bracher, F.,Papke, T.
, p. 805 - 810 (1995)
Pyridine alkaloids from Rubiaceae were prepared by palladium-catalyzed cross-coupling reactions of methyl 5-bromonicotinate (6) with various organometallic reagents.Baker's yeast reduction of the ketone 8 gave the levorotatory alcohol (S)-1.On this basis, the naturally occuring alcohol (+)-1 was assigned to be (R)-configurated.The alkaloids 1 and 4 show weak antimicrobial activities. - Keywords: Pyridine alkaloids; Palladium catalyst; Baker's yeast; Antimicrobial activity
A predictive model for additions to: N -alkyl pyridiniums
Knight, Brian J.,Tolchin, Zachary A.,Smith, Joel M.
supporting information, p. 2693 - 2696 (2021/03/18)
Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochemical outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Additionally, the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition. The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity. This journal is
Pleuromutilin derivatives such, its pharmaceutical composition and synthetic method and use thereof
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Paragraph 0089-0091, (2016/11/21)
The present invention relates to a class of pleuromytilin compounds represented by the following general formula (I), pharmaceutically acceptable salts and preparation methods thereof, and compositions comprising the compound represented by the general fo